Active Human CCL2
Cat.No. : | CCL2-108H |
Product Overview : | It is a synthetic Protein |
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Species : | Human |
Tag : | Non |
Description : | Monocyte chemotactic protein (MCP-1) is also known as monocyte chemotactic and activating factor (MCAF). It is the product of the human JE gene. The precursor form of MCP-1 consists of 99 amino acids with a signal peptide sequence consisting of 23 amino-terminal amino acids. The mature form of MCP-1 has 4 cysteine residues. The first two cysteine residues are in an adjacent position C-C, which characterizes MCP-1 as a member of the chemokine subfamily. MCP-1 is a nonglycosylated protein consisting of 76 amino acids with a molecular weight of 8700 daltons. MCP-1 mRNA expression can be induced in monocytes/macrophages, B lymphocytes, endothelial cells and astrocytoma cells by LPS. IL-1 will induce production of MCP-1 in fibroblasts, keratinocytes, hepatoma cells, and Type II pneumocytes. In vitro, MCP-1 will act on monocytes to initiate chemotaxis, induce superoxide anion release, induce the release of lysosomal enzymes and augment cytostatic activity. In vivo, MCP-1 will induce macrophage infiltration. The MCP-1 gene contains potential binding sites for several transcription factors, including AP-1, AP-2, NF-kB, and NF-IL6. |
Form : | Lyophilized |
Bio-activity : | Activity of this protein measured by its monocyte chemotactic activity and its ability to chemoattract CCR2A transfected mouse cells.ED50 for these assays were within the range of 10-30 ng/ml and 15-70 ng/ml. |
Applications : | Activity Assay |
Storage : | Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles |
Reconstitution : | Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly. |
Gene Name | CCL2 chemokine (C-C motif) ligand 2 [ Homo sapiens ] |
Official Symbol | CCL2 |
Synonyms | CCL2; chemokine (C-C motif) ligand 2; SCYA2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); C-C motif chemokine 2; GDCF 2; HC11; MCAF; MCP 1; MCP1; MGC9434; monocyte chemoattractant protein 1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; homologous to mouse Sig je; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys Cys); member 2; SMC CF; small-inducible cytokine A2; monocyte chemoattractant protein-1; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; |
Gene ID | 6347 |
mRNA Refseq | NM_002982 |
Protein Refseq | NP_002973 |
UniProt ID | P13500 |
Chromosome Location | 17q11.2-q21.1 |
Pathway | Activation of Genes by ATF4, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; |
Function | CCR2 chemokine receptor binding; CCR2 chemokine receptor binding; G-protein coupled receptor binding; chemokine activity; heparin binding; protein kinase activity; receptor binding; |
◆ Cell & Tissue Lysates | ||
CCL2-001MCL | Recombinant Mouse CCL2 cell lysate | +Inquiry |
Not For Human Consumption!
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