XAV-939, GMP Grade

• Cat.No.: XAV-939-07
• Product Overview: XAV-939 (GMP) is XAV-939 produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture.

Specification

• Description: XAV-939 is a tankyrase inhibitor.
• Form: Solid, White to off-white
• Target: PARP
• In Vitro: XAV-939 (GMP) (5 μM; 2 μM for 3 days; 1 μM) induces the differentiation of human pluripotent stem cells (hPSCs) into post-mitotic cortical neurons. XAV-939 (GMP) promotes the specification of the anterior central nervous system (CNS). RT-PCR Cell Line: Human pluripotent stem cells (hPSCs) Concentration: 5 μM, 2 μM, 1 μM Incubation Time: 3 days Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.
• CAS: 284028-89-3
• Formula: C14H11F3N2OS
• Molecular Mass: 312.31

Gene Information

• Pathway: Cell Cycle/DNA Damage; Epigenetics
• Official Symbol: XAV-939
• Synonyms: XAV-939