TFF2
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Official Full Name
trefoil factor 2 -
Overview
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. -
Synonyms
TFF2;trefoil factor 2;SML1, spasmolytic protein 1;spasmolysin;spasmolytic protein 1;spasmolytic polypeptide;SP;SML1
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TFF2 involved in several pathways and played different roles in them. We selected most pathways TFF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TFF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TFF2 has several biochemical functions, for example, CXCR4 chemokine receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFF2 itself. We selected most functions TFF2 had, and list some proteins which have the same functions with TFF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ASIC2,HNF4A,KIAA0368,TK1,UBLCP1,FOXR1,AMELX,PRSS2,SATB1,MKNK2 |
Interacting Protein
TFF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFF2.
FCRL4;PKM
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References
- Yu, Y; Jia, TZ; et al. Comparison of the anti-ulcer activity between the crude and bran-processed Atractylodes lancea in the rat model of gastric ulcer induced by acetic acid. JOURNAL OF ETHNOPHARMACOLOGY 160:211-218(2015).
- Belovari, T; Bijelic, N; et al. Trefoil factor family peptides TFF1 and TFF3 in the nervous tissues of developing mouse embryo. BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES 15:33-37(2015).
