TACR2
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Official Full Name
tachykinin receptor 2 -
Overview
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. -
Synonyms
TACR2;tachykinin receptor 2;NKNAR, TAC2R;substance-K receptor;NK2R;SKR;NK-2R;NK-2 receptor;substance K receptor;neurokinin 2 receptor;neurokinin A receptor;seven transmembrane helix receptor;NKNAR;TAC2R
Recombinant Proteins
- Mouse
- Rat
- Human
- Dog
- Oryctolagus cuniculus (Rabbit)
- Mus musculus
- Mesocricetus auratus
- Guinea pig
- Bovine
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
TACR2 involved in several pathways and played different roles in them. We selected most pathways TACR2 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TACR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | NR3C1,ADRB2A,PTGFR,TAAR12H,F2R,MC2R,LOC100328615,APLNRB,UTS2R,ADORA2AB |
| Calcium signaling pathway | TACR1B,GNA11B,CD38,DRD1B,NOS2,SLC8A1B,PDGFRB,GRIN1B,PRKCBA,CAMK2D |
Protein Function
TACR2 has several biochemical functions, for example, protein binding,substance K receptor activity,tachykinin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TACR2 itself. We selected most functions TACR2 had, and list some proteins which have the same functions with TACR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tachykinin receptor activity | TACR3,TACR3A,TACR1,TACR3L,TACR1B,TACR1A |
| protein binding | BEX2,MOB1A,TCHP,PHLDA1,ADD1,CD80,DPH2,HAND2,DRG2,PAK4 |
Interacting Protein
TACR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TACR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TACR2.
TAC1
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References
- Takeda, M; Miyake, M; et al. Proliferation of sensory C-fibers and subsequent neurogenic inflammation in rat airway induced by inhaled lipopolysaccharide. NEUROTOXICOLOGY 32:954-962(2011).
- Verhein, KC; Hazari, MS; et al. Three days after a single exposure to ozone, the mechanism of airway hyperreactivity is dependent on substance P and nerve growth factor. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 300:L176-L184(2011).
