SMYD2
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Official Full Name
SET and MYND domain containing 2 -
Overview
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 (PubMed;16805913)). -
Synonyms
SMYD2;SET and MYND domain containing 2;N-lysine methyltransferase SMYD2;HSKM B;KMT3C;ZMYND14;lysine N-methyltransferase 3C;histone methyltransferase SMYD2;zinc finger, MYND domain containing 14;SET and MYND domain-containing protein 2;HSKM-B;MG
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Insect Cell
- HEK293
- HEK293T
- His
- His&SUMO
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SMYD2 involved in several pathways and played different roles in them. We selected most pathways SMYD2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMYD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | TADA2B,VPS72,KDM5C,ACTL6A,SMARCD1,MSL3,ARID4A,SAP18,ARID5B,JMJD6 |
| Chromatin modifying enzymes | YEATS4,MSL2,CARM1,EP400,MTA2,CHD4,KAT6B,C17orf81,PRMT5,KDM5C |
| p53 pathway | PPP1R13L,HUWE1,TRIM28,KAT8,TTC5,FBXO11,E4F1,RASSF1,DYRK2,NEDD8 |
| PKMTs methylate histone lysines | DPY30,SMYD3,ATF7IP,RBBP5,SUZ12A,EHMT2,PRDM16,SETD3,ASH2L,SUZ12B |
Protein Function
SMYD2 has several biochemical functions, for example, RNA polymerase II core binding,histone methyltransferase activity (H3-K36 specific),metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMYD2 itself. We selected most functions SMYD2 had, and list some proteins which have the same functions with SMYD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARL6IP5,CAMKK1,PODXL2,ZNF490,HNRNPC,DPP3,KLB,NOX1,BNIP3,SKIL |
| protein-lysine N-methyltransferase activity | AAAS,METTL20,PRMT8B,METTL21C,IRF4,VCPKMT,METTL21A,SMYD2B,EHMT2,FAM86A |
| histone methyltransferase activity (H3-K36 specific) | ASH1L,SETD2,SMYD2A,NSD1,SMYD2B,SETD3,SETMAR |
| p53 binding | CHD8,SMARCA4,ZNF385A,KDM1A,PLK3,EHMT2,USP10,STK11,BLM,ZMAT3 |
| metal ion binding | PFAS,PDCD2,ZNF350,CYP2K19,WBP4,MAT2A,NRXN3A,KLF16,PPAT,SPNA1 |
| RNA polymerase II core binding | SMYD3,AGO2,PAF1,AGO1,SMYD2A,ZNF326,RPRD1B,PCF11,WAC,KIAA1967 |
Interacting Protein
SMYD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMYD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMYD2.
GEMIN2;AXIN1;VPS26A;EIF4E;SNRPB2;MYH1;MYH6;HNRNPL;PEBP1;GSK3B;RPS14;RPL23A;PTGES3;SF3A1;CDC37
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References
- Watanabe, T; Kobunai, T; et al. Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signalling pathways. EUROPEAN JOURNAL OF CANCER 47:1946-1954(2011).
