SELP
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Official Full Name
selectin P (granule membrane protein 140kDa, antigen CD62) -
Overview
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. -
Synonyms
SELP;selectin P (granule membrane protein 140kDa, antigen CD62);GRMP, selectin P (granule membrane protein 140kD, antigen CD62);P-selectin;CD62;CD62P;GMP140;PADGEM;PSEL;GMP-140;granule membrane protein 140;granulocyte membrane protein;CD62 antigen-like family member P;platelet alpha-granule membrane protein;leukocyte-endothelial cell adhesion molecule 3;platelet activation dependent granule-external membrane protein;GRMP;LECAM3;FLJ45155
Recombinant Proteins
- Rat
- Human
- Mouse
- Cynomolgus
- Zebrafish
- Sheep
- Bovine
- Mus musculus
- Rabbit
- SV40
- Rhesus macaque
- HEK293
- Mammalian Cells
- Human Cells
- E.coli
- CHO
- Fc
- His
- Non
- T7
- Avi
- Myc
- DDK
- KSI
Involved Pathway
SELP involved in several pathways and played different roles in them. We selected most pathways SELP participated on our site, such as Cell adhesion molecules (CAMs),Malaria,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SELP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | SELE,HBB-B1,ITGB2L,MYD88,Ccl12,ITGAL,THBS1,KLRK1,TNF,HBB |
| Cell adhesion molecules (CAMs) | ITGB2L,Siglec1,CLDNE,MPZL1,CLDN6,CLDN19,CNTNAP2A,ESAM,PTPRM,Ntng2 |
| Staphylococcus aureus infection | FGG,GM5077,FCAR,ICAM1,C3,ITGB2,HLA-DOA,FCGR3,HLA-DQA2,MBL1 |
Protein Function
SELP has several biochemical functions, for example, calcium-dependent protein binding,fucose binding,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SELP itself. We selected most functions SELP had, and list some proteins which have the same functions with SELP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIRPB1,MSLN,CNTROB,MARCKSL1,RAVER2,MYPOP,TRAF3,CRHR2,TUBA3D,C1QTNF9 |
| oligosaccharide binding | SELE,CHID1,RS1A,DCBLD1,LOXL2 |
| lipopolysaccharide binding | TLR2,KIAA0644,TLR4,PTAFR,SCARB1,CATHL3,P2RX7,BPIFC,RNASE7,LBP |
| calcium-dependent protein binding | CHP1,TNNI3,ANXA2,RBM22,NELF,MMP13,DDX5,RAC3,ALG2,MASP2 |
| glycosphingolipid binding | LYN,Il2,LAMC1,LAMB1,LAMA1,SELL,Cel |
| heparin binding | SERPIND1,PF4,FGFBP3,CXCL11,RSPO3,ADAMTS3,OVALX,FGF10,NAV2,SERPINA10 |
| fucose binding | FUOM,FUCA1,FUCA2 |
| sialic acid binding | AGRN,Siglece,ST8SIA3,ADIPOQ,SELE,FCN1,L1CAM,ST8SIA2 |
| glycoprotein binding | EDEM2,BBC3,B2M,TFR2,FBXO27,DNAJC5,Serpina1b,SDC1,RAB14,SERPINA1A |
Interacting Protein
SELP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SELP here. Most of them are supplied by our site. Hope this information will be useful for your research of SELP.
SELPLG
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