Recombinant Mouse SELP Protein, His\Avi-tagged

• Cat.No.: SELP-177M
• Product Overview: Biotinylated Recombinant Mouse P-selectin is produced by our Mammalian expression system and the target gene encoding Trp42-­Ala709 is expressed with a Avi, 6His tag at the C-terminus.

Specification

• Description: P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
• Source: Human Cells
• Species: Mouse
• Tag: His&Avi
• Form: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• AA Sequence: Trp42-Ala709
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient

Gene Information

• Gene Name: Selp selectin, platelet [ Mus musculus (house mouse) ]
• Official Symbol: SELP
• Synonyms: P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; PADGEM; Grmp; CD62P
• Gene ID: 20344
• mRNA Refseq: NM_011347.2
• Protein Refseq: NP_035477.1
• UniProt ID: Q01102