PRKAA1
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Official Full Name
protein kinase, AMP-activated, alpha 1 catalytic subunit -
Overview
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
PRKAA1;protein kinase, AMP-activated, alpha 1 catalytic subunit;5-AMP-activated protein kinase catalytic subunit alpha-1;AMPK;alpha;1;AMPKa1;AMPK alpha 1;AMPK subunit alpha-1;tau-protein kinase PRKAA1;AMP -activate kinase alpha 1 subunit;AMP-ac
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- Sf9 Insect Cell
- E.coli
- E. coli
- Mammalian Cell
- Insect cell
- Insect Cell
- Mammalian cells
- HEK293
- Insect (sf21)
- HEK293T
- His
- GST
- N-GST
- Non
- His&GST
- His&MBP
- His&T7
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PRKAA1 involved in several pathways and played different roles in them. We selected most pathways PRKAA1 participated on our site, such as FoxO signaling pathway,Regulation of autophagy,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | LEPA,POMCA,ADIPOR1,PRKAG2A,JAK2B,JAK2,CAMKK1A,NFKBIB,MAPK8B,G6PC |
| Insulin signaling pathway | PRKAG1,INSR,INS2,FOXO1,EIF4E1C,ARAF,MAP2K1,EIF4E2RS1,RPTOR,PRKAR1AB |
| FoxO signaling pathway | HOMER1,BCL6A,IRS2,PRKAG2,IGF1RB,SGK3,G6PC2,PRKAG3B,PIK3CG,INS2 |
| Hypertrophic cardiomyopathy (HCM) | MYL2,TPM4,ACTG1,TNNC1,ATP2A2,DMD,IL6,ITGB5,ITGA5,ACE |
| mTOR signaling pathway | EIF4E2RS1,EIF4E1B,ULK3,RPS6KB1B,CAB39L1,RRAGCA,PRKAA2,RPS6KB1,PIK3CD,PIK3CG |
| PIK-Akt signaling pathway | PPP2R1A,GH1,TCL1B1,FLT4,FGF2,CREB5,ANGPT1,KLK1B4,SPP1,PPP2CB |
| Non-alcoholic fatty liver disease (NAFLD) | UQCRB,NDUFS5,NDUFB9,NDUFA8,NDUFB2,NDUFC1,PRKAB1,COX7B2,NDUFA5,NDUFS2 |
| AMPK signaling pathway | PFKFB1,PCK2,CPT1B,PFKP,FOXO3,CPT1C,TBC1D1,ADIPOQ,ELAVL1,IRS2 |
| Oxytocin signaling pathway | NFATC4,PRKAG2,CD38,PPP1CC,MAPK3,PTGS2,GNAI3,CALM4,CALML5,MYL6 |
Protein Function
PRKAA1 has several biochemical functions, for example, AMP-activated protein kinase activity,ATP binding,[acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA1 itself. We selected most functions PRKAA1 had, and list some proteins which have the same functions with PRKAA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MYL6B,KIF3B,IGFN1,PYCARD,ZBED4,HPS6,PMEPA1,CLUAP1,ADD1,GRIN2D |
| chromatin binding | SOX10,NFKB1,POU4F2,PELP1,TOX3,SFPQ,APTX,PSIP1,CDK9,GLI2 |
| metal ion binding | GIT2,COL27A1,TRIM43B,ATP5S,RPS6KAL,Atp8a2,GATA5,ADIPOR2,POLI,ZNF395 |
| protein C-terminus binding | TOP2B,HIC2,AP2A1,PROP1,ABL1,PDZD3,NPAT,MKI67,SNX17,PEX1 |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity | PRKAA2 |
| protein kinase activity | SYK,CDK9,PRKCA,CAMKK1B,RPS6KA6,EPHB3A,BRAF,NIM1,STK24B,ERBB3B |
| tau-protein kinase activity | GSK3A,MARK2,MARK1,PHKG1,CSNK1D,PHKG2,MARK4,CDK5,GSK3B |
| kinase binding | CHP1,WWC2,TRIP6,WWC1,JAKMIP2,PPP1R9B,CDC37,DLG3,GFAP,PARK7 |
| cAMP-dependent protein kinase activity | PRKACA,PRKX,PRKACG,AKAP13,PRKACB,PRKAG1 |
Interacting Protein
PRKAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA1.
PRKAB2;PRKAG1
Resources
Research Area
Kinases and Phosphatases in Endothelial CellsHistone Phosphorylation
Intracellular Kinases in the Akt Pathway
Growth Hormone/IGF-I Axis
AMPK (AMP-activated Protein Kinases)
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References
