PARK7
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Official Full Name
parkinson protein 7 -
Overview
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
PARK7;parkinson protein 7;DJ1;DJ-1;HEL-S-67p;protein DJ-1;oncogene DJ1;epididymis secretory sperm binding protein Li 67p;Parkinson disease (autosomal recessive, early onset) 7
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mamanlian cells
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
- His&SUMO
- His&GST
- Flag
Involved Pathway
PARK7 involved in several pathways and played different roles in them. We selected most pathways PARK7 participated on our site, such as Alpha-synuclein signaling,Androgen receptor signaling pathway,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Androgen receptor signaling pathway | SMAD3B,NR2C2,POU2F1B,CREBBP,MYST2,DSTN,AES,TGFB1I1,PIAS3,RANBP9 |
| Alpha-synuclein signaling | BLK,STUB1,KLK6,CSNK2A1,TOR1A,FKBP1A |
| Parkinsons Disease Pathway | ATXN2,UBE2J2,SYT11,LRRK2 |
| Parkinsons disease | COX7A2,NDUFA7,UBE2L3,NDUFS1,VDAC1,NDUFV3,ATP5O,VDAC2,COX6B2,ATP5D |
| Synaptic Vesicle Pathway | STX1B,SYN1,SYP,SYN3,CPLX2,SYN2,DNM1L |
Protein Function
PARK7 has several biochemical functions, for example, L-dopa decarboxylase activator activity,androgen receptor binding,copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARK7 itself. We selected most functions PARK7 had, and list some proteins which have the same functions with PARK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | S100V2,SNCA,AOC1,LOXL3,RNF7,MT1,ABP1,MOXD1,MOXD2,P2RX4 |
| cytokine binding | KIT,NRP1,CSF1R,IFNGR1,LIFR,ELANE,CHRD,IL17F,CXCR4,CRLF1 |
| superoxide dismutase copper chaperone activity | CCS,ATP7A |
| scaffold protein binding | CACNA1H,PANX1,DSP,SRC,GRIN2A,IKBKB,NOS1,CACNA1G,CIT,P2RY1 |
| kinase binding | DLG4,SIT1,BARD1,MOBKL1A,TNFAIP3,PTPN22,CEBPB,HAP1,SP100,SNAI1 |
| peroxiredoxin activity | PRDX5,PRDX6 |
| ubiquitin-specific protease binding | CHMP3,MARCH6,DERL1,VCP,SART3,BAG6,SELS,RAD23A,AMFR,SYVN1 |
| transcription coactivator activity | MED23,APEX1,MYSM1,CCNE1,TAF12,TCF3,HCFC2,RBPMS,CITED2,MCIN |
| transcription factor binding | APBB3,PPP1R13BB,BCOR,TRIB2,HDAC4,SUMO1,KAT2B,DOT1L,NIF3L1,NFATC2 |
Interacting Protein
PARK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARK7.
FADD;PYCR1;AR
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References
- Saito, Y; et al. Oxidized DJ-1 as a possible biomarker of Parkinson's disease. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 54:138-144(2014).
- Chang, LC; Fan, CW; et al. Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer: Nrf2 Expression is Closely Correlated to Keap1 in the Tumor and Bach1 in the Normal Tissue. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 21:511-517(2013).
