MICA
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Official Full Name
MHC class I polypeptide-related sequence A -
Overview
MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, ??T cells and CD8+??T cells. Recognition of MICA and MICB by -
Synonyms
MICA;MHC class I polypeptide-related sequence A;PERB11.1;HLA class I antigen;stress inducible class I homolog;MHC class I chain-related protein A;MIC-A;FLJ36918;FLJ60820;MGC21250;MGC111087
Recombinant Proteins
- Human
- Cynomolgus
- HEK293
- E.coli
- Mammalian Cells
- CHO
- N-mFc
- C-His
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Fc
- Avi&Fc
- Non
- Avi&His
- DDK&Myc
- GST&His
- Avi&Fc&His
- GST
- Flag
Involved Pathway
MICA involved in several pathways and played different roles in them. We selected most pathways MICA participated on our site, such as Adaptive Immune System,Allograft Rejection,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MICA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | LAIR2,CD200,KLRF1,LILRB5,TREML1,LILRB4,SIGLEC6,KIR2DS2,KLRB1A,LILRA2 |
| Natural killer cell mediated cytotoxicity | ICAM1,FCGR4,ITGB2,NFATC2,PPP3CC,ULBP3,TNFRSF10B,PRKCA,KIR2DS3,TNFRSF10C |
| Adaptive Immune System | ASB18,LILRB1,RNF25,BLK,KIF2B,RNF34,AP2B1,MALT1,WWP1,STIM1B |
| Immune System | HUWE1,SIGLEC7,GRAP2A,MYO1C,DTX3L,RNF25,IFI35,S100A12,CASPB,BLMH |
| Allograft rejection | HLA-G,HLA-DOB,Fasl,HLA-DPA1,HLA-DRB1,CD40,IL5,HLA-DRB3,GZMB,H2-AA |
Protein Function
MICA has several biochemical functions, for example, NOT beta-2-microglobulin binding,natural killer cell lectin-like receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MICA itself. We selected most functions MICA had, and list some proteins which have the same functions with MICA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TNFSF10,CD163,EIF4A1,GLMN,ZNF32,GABBR2,HDDC2,PTGDS,TRIM59,DNPEP |
| natural killer cell lectin-like receptor binding | SAMD3,Mill2,RAET1G,ULBP3,RAET1E,RAET1D,RAET1L,Raet1c,HLA-E,CLEC2H |
Interacting Protein
MICA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MICA here. Most of them are supplied by our site. Hope this information will be useful for your research of MICA.
KLRK1;LGALS3;POT1
Resources
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References
- Fujita, H; Hatanaka, Y; et al. Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 63:217-227(2015).
- Flaxa, J; Rosner, A; et al. Methodological and clinical aspects of alloimmunization after granulocyte transfusion in patients undergoing allogeneic stem cell transplantation. TISSUE ANTIGENS 85:93-103(2015).
