Recombinant Human MICA Protein
Cat.No. : | MICA-823H |
Product Overview : | Recombinant human MICA protein without tag was expressed in HEK293. |
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Species : | Human |
Source : | HEK293 |
Protein Length : | 383 |
Description : | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. |
Form : | Lyophilized |
Molecular Mass : | 33.6 kDa |
AA Sequence : | MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA |
Purity : | > 98% |
Applications : | Migration Assay; |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name | MICA MHC class I polypeptide-related sequence A [ Homo sapiens (human) ] |
Official Symbol | MICA |
Synonyms | MICA; MHC class I polypeptide-related sequence A; PERB11.1; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A; MIC-A; FLJ36918; FLJ60820; MGC21250; MGC111087; |
Gene ID | 100507436 |
mRNA Refseq | NM_000247 |
Protein Refseq | NP_000238 |
MIM | 600169 |
UniProt ID | Q29983 |
◆ Recombinant Proteins | ||
MICA-6630H | Recombinant Human MICA Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
MICA-705H | Active Recombinant Human MICA, Fc Chimera | +Inquiry |
MICA-1778H | Recombinant Human MICA Protein, His&GST-tagged | +Inquiry |
MICA-30099TH | Recombinant Human MICA | +Inquiry |
MICA-1660C | Recombinant Cynomolgus MICA protein, His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
MICA-1941HCL | Recombinant Human MICA cell lysate | +Inquiry |
Not For Human Consumption!
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