METAP1
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Official Full Name
methionyl aminopeptidase 1 -
Overview
Removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle. -
Synonyms
METAP1;methionyl aminopeptidase 1;methionine aminopeptidase 1;KIAA0094;MAP1A;MetAP1A;Peptidase M;DKFZp781C0419;MAP 1;MetAP 1;Peptidase M 1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- HEK293
- E.coli
- Insect Cells
- Mammalian Cells
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- Fc
- His
- GST
- Non
- His&T7
- Avi&Fc&His
- DDK&Myc
Involved Pathway
METAP1 involved in several pathways and played different roles in them. We selected most pathways METAP1 participated on our site, such as Inactivation, recovery and regulation of the phototransduction cascade,Signal Transduction,The phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with METAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | GREM2,PYGO2,EDN3,SOX9A,OPN4.1,DISP2,ARHGAP11A,CDC37,WIPF2,BCO2 |
| The phototransduction cascade | METAP2,GUCA1E,RGS9BP,CNGA1,GRK7,METAP2B,NMT1A,SAGB,RLN1,PPEF1 |
| Inactivation, recovery and regulation of the phototransduction cascade | CNGA1,GRK7,RGS9BP,GNB5A,RLN1,NMT1A,GUCA1E,METAP2,METAP2B,METAP2A |
| Visual phototransduction | DHRS3A,SDR9C7,RBP3,LRP12,PPEF1,IRBP,RLBP1A,CNGA1,GUCA1E,ABCA4A |
Protein Function
METAP1 has several biochemical functions, for example, aminopeptidase activity,metal ion binding,metalloexopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by METAP1 itself. We selected most functions METAP1 had, and list some proteins which have the same functions with METAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloexopeptidase activity | METAP2A,RNPEP,METAP1D,NPEPL1,NUDT16,METAP2B,ERAP1,METAP2,DPEP1,DPEP2 |
| metal ion binding | PRIM1,NRXN2,ACY3,NAIP7,CLCA2,ZNF526,ZFYVE28,ZFP503,PAPL,PAK3 |
| aminopeptidase activity | METAP2A,XPNPEP1,CTSH,Ctsl,XPNPEP3,PHEX,TPP2,BLMH,LAP3,XPNPEP2 |
Interacting Protein
METAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of METAP1.
CBWD1;SMAD9;HNRNPU
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References
- Ahsan, F; Arif, A; et al. Characterization and bioassay of post-translationally modified interferon alpha-2b expressed in Escherichia coli. JOURNAL OF BIOTECHNOLOGY 184:11-16(2014).
- Poreba, M; Gajda, A; et al. S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. BIOCHIMIE 94:704-710(2012).
