KAT2B
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Official Full Name
K(lysine) acetyltransferase 2B -
Overview
p300/CBP-associated factor (PCAF), also known as lysine acetyl-transferase 2B (KAT2B), is a transcriptional adaptor protein and histone acetyl-transferase (HAT) that functions as the catalytic subunit of the PCAF transcriptional co-activator complex (1). -
Synonyms
KAT2B;K(lysine) acetyltransferase 2B;p300/CBP associated factor , PCAF;histone acetyltransferase KAT2B;GCN5;GCN5L;P/CAF;histone acetylase PCAF;CREBBP-associated factor;p300/CBP-associated factor;lysine acetyltransferase 2B;histone acetyltransfe
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Sf9 Insect Cell
- Sf21 Insect Cell
- Insect Cell
- E. coli
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cell
- HEK293T
- In Vitro Cell Free System
- Non
- His
- Flag
- N-His&C-FLAG
- GST
- Myc&DDK
Involved Pathway
KAT2B involved in several pathways and played different roles in them. We selected most pathways KAT2B participated on our site, such as Notch signaling pathway,Thyroid hormone signaling pathway,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DLL4,DVL1B,LNX1,MAML1,JAG1A,NOTCH2,KAT2A,MFNG,MARK2,NCOR2 |
| Viral carcinogenesis | VDAC3,HIST1H2BP,MAPK1,LYN,PSMC1,BAX,SCRIB,GTF2H2,PIK3R1,HPN |
| Thyroid hormone signaling pathway | FOXO1,STAT1,ATP1A1,KAT2A,KRAS,PLCB3,HIF1A,PIK3CB,PLCB1,HRAS |
| HTLV-I infection | IL2RB,ETS2,WNT10B,IL1R2,BCL2L1,CD3G,PPP3R2,SLC25A5,PIK3CA,MAP3K14 |
Protein Function
KAT2B has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,acetyltransferase activity,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT2B itself. We selected most functions KAT2B had, and list some proteins which have the same functions with KAT2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | CARM1,MAGED1,NCOA4,RFXAP,MED26,TAF10,MLL5,NCOA1,PRMT2,CBFB |
| lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | ESCO2,NAT8B,EP300,NAT8,CEACAM21,RHBDL1 |
| histone deacetylase binding | MAGEA2,HIF1A,WDTC1,SIX3,RAD9A,MAPK8,MECP2,HIST1H1B,NIPBL,MEF2B |
| acetyltransferase activity | MBOAT4,EP300,CML5,NAT14,CML2,DGAT2L6,KAT5,AANAT1,Nat3,HHAT |
| histone acetyltransferase activity | TAF1,MGEA5,METTL8,CLOCK,KAT7B,HAT1,vnc,NCOA3,KAT7A,GTF3C4 |
| transcription factor binding | ARNT,SP100,AHR,UBE2I,MDFI,NKX3-1,CHCHD2,GTF2B,FOXF2,KDM1A |
| protein binding | KIT,NME7,FTL,ARID3A,STAG1,CLOCK,GFM2,SCNM1,P2RY1,SLC11A2 |
| RNA polymerase II regulatory region sequence-specific DNA binding | JARID2,ZNF549,DLX2,E4F1,SOHLH1,SP3,ATF4,XBP1,CREB3L3,BARHL1A |
| histone acetyltransferase binding | TAF7L,PAX6,MTF1,FOXP3,MEF2A,PCNA,GLI3,CEBPB,CREB1,TAF7 |
Interacting Protein
KAT2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT2B here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT2B.
BUB1B;E7;p03255-2
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