ITGA4
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Official Full Name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -
Overview
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. -
Synonyms
ITGA4;integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor);IA4;CD49D
Recombinant Proteins
- Mouse
- Human
- CHO
- E.coli
- Human Cells
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi&Fc&His
- GST&His
- DDK&Myc
- GST
- Flag
Involved Pathway
ITGA4 involved in several pathways and played different roles in them. We selected most pathways ITGA4 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | FGFR4,FGF8,LAMA1,ITGA5,MAP2K1,ITGB7,YWHAE,NGF,ITGA9,PIK3CB |
| Focal adhesion | ACTB,THBS4A,PAK3,PRKCA,ACTN1,PAK1,PPP1CA,MYL12.1,MYLK4,PDGFB |
| Regulation of Actin Cytoskeleton | RAC3A,ARPC5A,PDGFRB,FGF13A,MSN,PFN3,VCLA,TMSB,SSH2,RAF1B |
| Leishmaniasis | FCGR1,HLA-DQA1,ITGB1,NCF4,FCGR3,HLA-DPA1,MARCKSL1,MAPK1,HLA-DQA2,IL12A |
| Hematopoietic cell lineage | GP1BB,Il6ra,Itgam&Itgb2,HLA-DRB5,IL5RA,IL5,CD1B,CD1E,CD1D2,CR1 |
| ne network for IgA production | MAP3K14,CXCL12A,MHC2DEB,CXCR4,MHC2DAB,IL6,CD28,CCL25,HLA-DRA,TGFB1A |
| Dilated cardiomyopathy | CACNG4,ITGA10,MYBPC3,ITGB7,TGFB3,DES,ITGAV,TNNI3,TGFB2,LMNA |
| ECM-receptor interaction | SV2A,HMMR,LAMB2,LAMA1,SDC1,CD47,THBS3,VTNA,COL6A1,COL27A1A |
| Cell adhesion molecules (CAMs) | CLDN15LA,HLA-DOA,BLB1,ITGB7,PVRL2,HLA-DQA1,CLDN10,CDH1,MHC2A,NLGN2A |
Protein Function
ITGA4 has several biochemical functions, for example, cell adhesion molecule binding,fibronectin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA4 itself. We selected most functions ITGA4 had, and list some proteins which have the same functions with ITGA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibronectin binding | IGFBP5A,CTGF,LPA,CTSL1,HSD17B12,IGFBP5B,PLEKHA2,IGFBP5,ITGB1,ITGB1A |
| protein antigen binding | H2-AB1,KLRC2,KLRD1,EP300 |
| metal ion binding | NR5A1A,DMRT3A,ADSSL,VPS18,PRKAA1,ZDHHC18,STAC3,NOX1,GALNT6,AKAP8L |
| protein binding | ZBTB26,CD48,IKBIP,SNRNP40,ANAPC4,ATG9A,PIWIL1,POLD2,ATP11C,BLOC1S1 |
| cell adhesion molecule binding | NLGN4Y,CD1D,CPE,JUP,NLGN4X,CD200,PVRL1,NRXN3,LPHN1,ITGB3 |
Interacting Protein
ITGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA4.
PXN;ITGB1;VCAM1;LYN;TGFB1I1;LPXN;ITGB1;FLNA
Resources
Research Area
Endothelial Cell MarkersOther CD Antigen
Granulocyte Markers
Integrins
Focal Adhesion Proteins in VSMC
Epithelial Cell Markers and Intracellular Molecules
Basophils
Eosinophils
Neutrophils
Neural Crest Cell Markers
Adipose-derived Stem Cell Markers
B Cell Chemotaxis, Migration, and Adhesion
T Cell Migration
CD Antigen (Granulocyte Markers)
CD Antigen (Neutrophils)
CD Antigen (T Cell Migration/Adhesion)
Asthma Therapeutic Targets
Rheumatoid arthritis Therapeutic Targets
Co-stimulatory Molecules
Macrophage Markers
Monocyte Markers
Integrins in Focal Adhesions
Dendritic Cell Adhesion and Migration
Dendritic Cell Co-stimulatory Molecules
MDSC Phenotyping - Positive Markers
Related Services
Related Products
References
- Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
- Reindel, R; Baker, SC; et al. Integrins alpha 4 and alpha M, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. PEDIATRIC RESEARCH 73:332-336(2013).
