ISG15
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Official Full Name
ISG15 ubiquitin-like modifier -
Overview
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] -
Synonyms
ISG15;ISG15 ubiquitin-like modifier;G1P2;IP17;UCRP;IFI15;hUCRP;ubiquitin-like protein ISG15;ubiquitin cross-reactive protein;interferon-stimulated protein, 15 kDa;interferon-induced 17-kDa/15-kDa protein;interferon, alpha-inducible protein (clone IFI-15K)
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Bovine
- E.coli
- Mammalian Cell
- Human Cell
- HEK293
- HEK293T
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- StrepII
- Calmodulin
- Myc&DDK
- His&Fc&Avi
- GST
- His&GFP
- N-His&C-Myc
- Flag
Involved Pathway
ISG15 involved in several pathways and played different roles in them. We selected most pathways ISG15 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISG15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | CXCL8B.3,RIPK1,IFNA12,MAVS,DDX3X,CASP8,AZI2,IKBKG,IFNA8,Ifna11 |
Protein Function
ISG15 has several biochemical functions, for example, protein binding,protein tag. Some of the functions are cooperated with other proteins, some of the functions could acted by ISG15 itself. We selected most functions ISG15 had, and list some proteins which have the same functions with ISG15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tag | SUMO1,SUMO4,SUMO3B,RNF41,SUMO2,SUMO2B,UBL5,SUMO3A,SUMO3,NFATC2IP |
| protein binding | COL17A1,KLF2,BEND7,CCDC28A,CBX7,TMEM183A,PGK1,PRC1,AHNAK2,ETV4 |
Interacting Protein
ISG15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISG15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISG15.
UBA7;USP18;FLNB;PPM1B;ELF3
Resources
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References
- Baez-Santos, YM; St John, SE; et al. The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds. ANTIVIRAL RESEARCH 115:21-38(2015).
- Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).
