IL24
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Official Full Name
interleukin 24 -
Overview
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
IL24;interleukin 24;ST16;interleukin-24;C49A;FISP;IL 4 induced secreted protein;IL 24;IL10B;mda 7;melanoma differentiation association protein 7;Mob 5;suppression of tumorigenicity 16 (melanoma differentiation);melanocyte-associated Mda-7;IL
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- CHO
- Mammalian cells
- S.cerevisiae
- Mammalian Cell
- Human Cell
- Human Cells
- HEK293T
- Wheat Germ
- GST
- His
- Fc
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- His&GST
- mFc
Involved Pathway
IL24 involved in several pathways and played different roles in them. We selected most pathways IL24 participated on our site, such as Cytokine-cytokine receptor interaction,IL23-mediated signaling events,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL23-mediated signaling events | IL17F,IL23R |
| Jak-STAT signaling pathway | PIK3CB,IL9,SOCS1A,OSMR,Gh,EP300,Ifnl2,AOX4,SOCS4,IL21R.1 |
| Cytokine-cytokine receptor interaction | PRL2,GH2,INHBC,IL8L1,CXCL12,BMPR1BA,BMPR2B,KIT,MPL,CSF2RB |
| Senescence and Autophagy | LC3,IGFBP7,GABARAP,ATG7,IGFBP5,CREG1,RSL1D1,RB1CC1,IFI16,ING2 |
Protein Function
IL24 has several biochemical functions, for example, cytokine activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL24 itself. We selected most functions IL24 had, and list some proteins which have the same functions with IL24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARHGEF40,PARP9,CSNK1G1,ZFPM2,HRAS,ADRBK1,PDGFRA,AMDHD2,DUT,ACTN2 |
| cytokine activity | TGFB3,C1QTNF4,BMP8A,IL28A,SCGB3A1,BMP8B,IL20,IL18,IFNK,HMGB1A |
Interacting Protein
IL24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL24 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL24.
CHEK2;PARP1;RAD51;ATM;HMMR;BAG4;HRAS;KRAS;RARG;APC;AKT1;LSP1;PIK3CA;CCR5;PTEN
Resources
Research Area
Multiple Sclerosis and Myelin Related MoleculesT Cell Cytokine Signaling
IL-10 Family Ligands
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References
- Xu, J; Mo, YW; et al. Conditionally replicative adenovirus-based mda-7/IL-24 expression enhances sensitivity of colon cancer cells to 5-fluorouracil and doxorubicin. JOURNAL OF GASTROENTEROLOGY 48:203-213(2013).
- Bakshi, S; Zhang, X; et al. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. ENVIRONMENTAL HEALTH PERSPECTIVES 116:769-776(2008).
