Recombinant Human IL24 protein, His-tagged

• Cat.No.: IL24-589H
• Product Overview: Recombinant Human IL24 (Q13007) aa. (Gly51~Leu206) fused with His tag was produced in E. coli cells.

Specification

• Description: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 19.5kDa; Accurate Molecular Mass: 18kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Gly51~Leu206
• Purity: >92%
• Characteristic: Isoelectric point is 8.6.
• Applications: Cell culture; Activity Assays; In vivo assays.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 0.05% sarcosyl and 5% trehalose.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex

Gene Information

• Gene Name: IL24 interleukin 24 [ Homo sapiens (human) ]
• Official Symbol: IL24
• Synonyms: IL24; interleukin 24; C49A; FISP; MDA7; MOB5; ST16; IL10B; interleukin-24; IL-4-induced secreted protein; melanocyte-associated Mda-7; melanoma differentiation-associated gene 7 protein; suppression of tumorigenicity 16 (melanoma differentiation)
• Gene ID: 11009
• mRNA Refseq: NM_001185156.1
• Protein Refseq: NP_001172085.1
• UniProt ID: Q13007