IFNGR1
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Official Full Name
IFNGR1 interferon gamma receptor 1 -
Overview
It reacts with CD119, the alpha chain of the interferon gamma (IFN-gamma) receptor. This receptor is expressed by mouse leukocytes, endothelial, and epithelial cells, but not by mature erythrocytes. This antibody recognizes an epitope (susceptible to certain fixatives) in the ligand-binding site of the receptor. It can block the binding of mouse IFN-gamma; therefore, it can inhibit IFN-gamma mediated effects including the activation of mouse macrophages for tumor cell killing. IFN-gamma has been reported to induce the expression of Ly-6A/E antigen on cell lines and normal B lymphocytes, and the antibody is capable of inhibiting the IFN-gamma.induced expression of Ly-6A/E on the mouse B lymphoma line A20. The binding of the antibody to CD119 is inhibited by IFN-gamma. This antibody reportedly does not have any agonist effect. -
Synonyms
IFNGR1;interferon gamma receptor 1;IFNGR;CD119;CDw119;AVP, type 2;IFN-gamma-R1;CD119 antigen;IFN-gamma receptor 1;antiviral protein, type 2;immune interferon receptor 1;interferon-gamma receptor alpha chain;FLJ45734
Recombinant Proteins
- Human
- Cynomolgus
- Rat
- Rhesus macaque
- Mouse
- Chicken
- Zebrafish
- Mus musculus
- HEK293
- Human Cell
- Insect Cell
- Sf9 Insect Cell
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293T
- E.coli expression system
- Fc
- His
- His&Fc
- Non
- hIgG4
- His&T7
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
- C-His-Flag
Involved Pathway
IFNGR1 involved in several pathways and played different roles in them. We selected most pathways IFNGR1 participated on our site, such as Cytokine-cytokine receptor interaction,HIF- signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leishmaniasis | HLA-DQB1,TLR4,MAPK13,TLR2,PTPN6,FCGR1,IFNGR2,IL12B,HLA-DRA,NCF1 |
| Osteoclast differentiation | PIK3CA,LILRA5,AKT1,NCF1,FCGR2B,NCF4,PIK3R3,PIK3CG,PPP3CC,OSCAR |
| Salmonella infection | MAPK3,MAPK14A,ARPC5L,KLC1A,IL8L2,DYNC1I1,MAPK12A,RAB7B,IL6,PFN2 |
| Tuberculosis | IFNA6,MAPK12,CAMK2G,IFNA4,CASP9,PPP3R1,TLR2,HLA-DMA,PPP3R2,IFNA1 |
| Cytokine-cytokine receptor interaction | TGFBR1B,CSF2RA,THPO,TNFSF13,Ifnlr1,ACVR2A,TNFRSF8,CCL17,IL12B,IL9R |
| Jak-STAT signaling pathway | CSH1,IL22RA2,IFNPHI3,STAT5B,AOX3,GHR,MCL1,CCND2,MYCB,PIK3R3 |
| HIF- signaling pathway | INSR,SERPINE1,PLCG1,TLR4,ANGPT1,MAP2K2,ENO3,Il6ra,EPO,NOS3 |
| Influenza A | TMPRSS13,PYCARD,LOC100033925,NXT2,IFNG,HLA-DQB1,IFNA4,CXCL8,CYCS,NXF3 |
| Toxoplasmosis | MYD88,MAPK10,HLA-DOA,HSPA8,TAB2,HSPA2,HSPA1A,IL10RA,HLA-DRB3,ALOX5 |
Protein Function
IFNGR1 has several biochemical functions, for example, cytokine binding,interferon-gamma receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNGR1 itself. We selected most functions IFNGR1 had, and list some proteins which have the same functions with IFNGR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interferon-gamma receptor activity | IFNGR2 |
| protein binding | C2orf29,APOH,RDH12,FLOT2,KATNA1,CBFA2T2,STK11,PTPRE,ALPP,AP3M1 |
| cytokine binding | NRP1,IL31RA,ELANE,CHRD,CXCR4,TNFRSF11A,Fzd4,LIFR,NRP2,KIT |
Interacting Protein
IFNGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNGR1.
STAT1;IFNG;c-fos promoter region;NFKB1;purL;fruB;Stat3
IFNGR1 Related Signal Pathway
Resources
Research Area
Cytokine and Growth Factor Receptors on VSMCMultiple Sclerosis and Myelin Related Molecules
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
T Cell Cytokine Signaling
Macrophage Marker CD Antigen
CD Antigen (Helper T Cells)
Interferon receptor
T Follicular Helper (Tfh) Cells
Th1 Cells
Th2 Cells
IL-10 Family Receptors
Related Services
Related Products
References
- Ciftdogan, DY; Onay, H; et al. IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine. FUTURE VIROLOGY 9:123-130(2014).
- Lee, SH; Carrero, JA; et al. Identifying the Initiating Events of Anti-Listeria Responses Using Mice with Conditional Loss of IFN-gamma Receptor Subunit 1 (IFNGR1). JOURNAL OF IMMUNOLOGY 191:4223-4234(2013).
