IFNAR2
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Official Full Name
interferon (alpha and beta) receptor 2 -
Overview
This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1. IFNAR1 and IFNAR2 are coexpressed on nearly all cells and make up the heterodimeric receptor that binds a -
Synonyms
IFNAR2;interferon (alpha and beta) receptor 2;interferon alpha/beta receptor 2;IFN-R-2;interferon receptor 2c;IFN-alpha/beta receptor 2;type I interferon receptor 2;interferon-alpha/beta receptor 2;type I interferon alpha/beta receptor 2a;Ifnar-2
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Rat
- E.coli
- HEK293
- Mammalian cells
- Human Cell
- C-His
- Mammalian Cell
- Insect Cells
- Insect cells
- Yeast
- E.coli expression system
- GST
- His
- Fc
- His&T7
- Non
- His&Fc
- His&Fc&Avi
- His&SUMO
Involved Pathway
IFNAR2 involved in several pathways and played different roles in them. We selected most pathways IFNAR2 participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNAR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL22,CSF2RA,XCR1,CCL25B,Il23a,EDA2R,AMHR2,CD40,CCL20B,HGF |
| PIK-Akt signaling pathway | NFKB1,ITGB4,LAMA4,RPTOR,PTK2,TNC,IFNA6,IFNA16,AKT1,THBS4 |
| Toll-like receptor signaling pathway | AKT2L,IL8L2,CD86,MAPK12B,IL1B,PIK3R3A,CCL5,MAPK12,IL-8,PIK3R3 |
| Measles | PIK3CG,EIF2AK1,EIF3H,STAT3,IFNA6,Fasl,CBLB,CD46,IKBKE,TLR9 |
| Osteoclast differentiation | TEC,LILRB4,LILRA3,RAC1,TNFRSF11B,TREM2,FCGR1A,OSCAR,SOCS3,FOSB |
| Influenza A | OAS2,PIK3CA,TNFSF10,IL33,MAPK11,CYCS,NXT2,EIF2AK2,HLA-DQA1,TYK2 |
| Jak-STAT signaling pathway | IFNB1,IL15,PIAS4B,IL21,CTF1,IFNPHI1,MTOR,IL20RA,BCL2,SOCS3 |
| Natural killer cell mediated cytotoxicity | HLA-E,IFNA4,KLRC3,MAPK1,PIK3CA,PRKCA,Raet1a,PIK3R5,FYN,TNFSF10 |
| Hepatitis C | CLDN15,CLDN10,ARAF,PPP2R2B,OAS1,TNFRSF1A,PIAS1,IFNA6,MAPK1,MAPK12 |
Protein Function
IFNAR2 has several biochemical functions, for example, protein binding,protein kinase binding,type I interferon binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNAR2 itself. We selected most functions IFNAR2 had, and list some proteins which have the same functions with IFNAR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | MAP3K5,PPP1R12B,BCL2L1,EPHA1,DNAJC3,SYN1,TCTN2,HIF1A,AKAP5,DLG1 |
| protein binding | PPP3CA,HIST1H2BB,RPL15,PEF1,KCTD13,FBXO5,ITGB1BP3,BNIP3L,TAF9,PRDM7 |
| type I interferon receptor activity | IFNAR1 |
Interacting Protein
IFNAR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNAR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNAR2.
IRF9;JAK1;GNB2L1;CREBBP;STAT2;IFNA2
IFNAR2 Related Signal Pathway
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References
- Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
- Kuruganti, S; Accavitti-Loper, MA; et al. Production and characterization of thirteen human type-I interferon-alpha Mark subtypes. PROTEIN EXPRESSION AND PURIFICATION 103:75-83(2014).
