Recombinant Human HNRNPA2B1 Protein, His-tagged

• Cat.No.: HNRNPA2B1-461H
• Product Overview: Recombinant Human HNRNPA2B1(Arg21~Gly103) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 10.8kDa
• Identity: Reconstitute in PBS or others
• Protein length: Arg21~Gly103
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Homo sapiens ]
• Official Symbol: HNRNPA2B1
• Synonyms: HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1; HNRPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein; RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; FLJ22720; DKFZp779B0244
• Gene ID: 3181
• mRNA Refseq: NM_002137
• Protein Refseq: NP_002128
• MIM: 600124
• UniProt ID: P22626

Reviews

08/29/2022

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12/24/2021

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07/07/2017

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Q&As

How does HNRNPA2B1 contribute to mRNA splicing?

It influences mRNA splicing, affecting transcript diversity.

How do genetic variations in HNRNPA2B1 affect RNA metabolism?

Genetic mutations in HNRNPA2B1 impact RNA splicing and processing.

What is the primary role of HNRNPA2B1 in RNA processing?

HNRNPA2B1 is key for RNA processing and metabolism.

How does HNRNPA2B1 interact with other RNA-binding proteins?

HNRNPA2B1 works with RNA-binding proteins to manage RNA regulation.

What is the impact of altered HNRNPA2B1 activity on neurodegenerative diseases?

Altered HNRNPA2B1 activity is linked to neurodegenerative conditions.

What role does HNRNPA2B1 play in gene regulation?

HNRNPA2B1 regulates gene expression at the RNA level.

What potential therapeutic applications arise from targeting HNRNPA2B1 in RNA-based disorders?

Targeting HNRNPA2B1 could treat RNA processing-related diseases.