GSK3B
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Official Full Name
glycogen synthase kinase 3 beta -
Overview
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] -
Synonyms
GSK3B;glycogen synthase kinase 3 beta;glycogen synthase kinase-3 beta;GSK-3 beta;GSK3beta isoform;serine/threonine-protein kinase GSK3B
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Insect Cells
- E.coli
- Mammalian Cells
- Sf9 Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- Sf21 Cells
- His
- GST
- Flag
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway,Chemokine signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | SHC3,FN1,THBS3,MYL12A,HGF,VEGFAA,PAK2B,PAK6,MYL12.1,MAPK6 |
| Pathways in cancer | IL6,GNG2,FGF19,FGF18,TGFB1,AHA-1,WNT9B,CCNE2,RAC2,GNG4 |
| B Cell Receptor Signaling Pathway | CD81,MALT1,FCGR2B,IKBKB,CD79B,CTNNB2, Cd79b,VAV2,NFKBIA,GSK3AB |
| Non-alcoholic fatty liver disease (NAFLD) | UQCR11,IL1A,NDUFB9,IL1B,NDUFAB1,TNF,GSK3A,PKLR,NDUFB3,CDC42 |
| Endometrial cancer | BRAF,MAPK3,PTEN,RAF1,PIK3R3,MAP2K1,CTNNA3,ERBB2,AXIN1,AKT2 |
| Insulin resistance | PRKAB1A,MLXIPL,PTENB,PRKAG3,PYGMA,PRKCE,RPS6KB1B,PPARGC1B,PRKCBA,MTOR |
| Epstein-Barr virus infection | CD40,HDAC4,BCL2,PLCG2,IFNG,MAPK13,GTF2B,SKP2,RELA,POLR3F |
| Signaling pathways regulating pluripotency of stem cells | WNT5A,NRAS,INHBA,LIFR,BMI1,WNT16,WNT1,PIK3R2,MAP2K1,FGF2 |
| HTLV-I infection | ANAPC5,BUB1B,CD3E,XPO1,PDGFRA,POLE2,MRAS,HLA-F,NRP1,HLA-DRA |
Protein Function
GSK3B has several biochemical functions, for example, ATP binding,NF-kappaB binding,RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SLC11A2,F5,PSG1,MLLT10,POMP,CDK9,MTMR6,HER11,ZFAND2B,CCDC12 |
| tau-protein kinase activity | PRKAA1,GSK3A,MARK1,PHKG2,CDK5,CSNK1D,PHKG1,MARK2,MARK4 |
| protein kinase A catalytic subunit binding | PKIA,RYR2,CSK,PRKAR2B,PRKAR1A,SOX9,GSK3A,EZR,PRKAR2A,KCNQ1 |
| p53 binding | SETD8,SMARCA4,CDKN2A,EHMT1,HSPD1,CDK5,PLK3,KDM1A,SETD7,ZFP385C |
| ubiquitin protein ligase binding | CLU,NAE1,FLJ11011L,CDC34B,EGR2,POLR2A,DNAJA1,SUMO2,NKD2,TRIOBP |
| NF-kappaB binding | FOXP3,COMMD6,CDKN2A,TAF4B,ANKRD42,SNAI1A,HDAC2,AP1S2,NFKBID,FAF1 |
| ATP binding | MAPK4,NRBP1,GRK4,PAK7,CARKD,TRMU,CCT6A,UBE2IB,DDX10,MAP2K5 |
| protein serine/threonine kinase activity | PAK2A,ADCK1,DAPK1,MINK1,MARK1,MAPKAPK2,CSNK1E,ZNF143B,NIM1K,CAMK2B1 |
| protein kinase binding | FAM83D,ZC3HC1,GCSAM,SV2A,PTEN,TCTN2,CNTLN,TICAM1,CNPPD1,PRKAG3 |
Interacting Protein
GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1
GSK3B Related Signal Pathway
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References
- Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
- Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).
