Recombinant Rat Gsk3b Protein, His-tagged

• Cat.No.: Gsk3b-1603R
• Product Overview: Recombinant Rat Gsk3b Protein (Lys122-Thr375) with N-His tag was expressed in E. coli.

Specification

• Species: Rat
• Source: E.coli
• Tag: His
• Protein Length: Lys122-Thr375
• Description: Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including regulation of neuron projection development; regulation of synapse organization; and response to peptide. Located in several cellular components, including dendritic spine; membrane raft; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); diabetic encephalopathy; mental depression; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 32.6 kDa
  Accurate Molecular Mass: 33 kDa
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Gsk3b glycogen synthase kinase 3 beta [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Gsk3b
• Synonyms: GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; FA; factor A; GSK-3 beta; serine/threonine-protein kinase GSK3B
• Gene ID: 84027
• mRNA Refseq: NM_032080
• Protein Refseq: NP_114469
• UniProt ID: P18266