GADD45A
-
Official Full Name
growth arrest and DNA-damage-inducible, alpha -
Overview
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
GADD45A;growth arrest and DNA-damage-inducible, alpha;DDIT1;growth arrest and DNA damage-inducible protein GADD45 alpha;GADD45;DDIT-1;DNA damage-inducible transcript-1;DNA-damage-inducible transcript 1;DNA damage-inducible transcript 1 protein;gr
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Rat
- E.coli
- Insect Cells
- Mammalian Cells
- Rhesus Macaque
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- GST&His
- His
- Non
- Flag&His&Twin Strep
- Avi&Fc&His
- His&T7
- DDK&Myc
- His&SUMO
Involved Pathway
GADD45A involved in several pathways and played different roles in them. We selected most pathways GADD45A participated on our site, such as ATF-2 transcription factor network,ATM Signaling Pathway,Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GADD45A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | ODF2,NEK6,CDK4,NCAPH2,YWHABA,CDC20,LIN52,SKP1,NIPBL,GORASP2 |
| ATM Signaling Pathway | CREB1 |
| FoxO family signaling | ZFAND5,CSNK1G2,MST1,CSNK1G3,FBXO32 |
| DNA damage response | RAD1,RAD9A,RAD17,CHEK2,CDK5,HUS1B,TLK2,DDB2,GADD45G |
| Direct p53 effectors | CTSD,PPM1J,CEBPZ,TRIAP1,S100A2,CCNK,ARID3A,FOXA1,ZNF385A,SCN3B |
| Aurora A signaling | TPX2,OAZ1,NDEL1,TACC1,AURKAIP1,TACC3,TDRD7,CENPA,AURKB |
| ATF-2 transcription factor network | JUN,CDK4,CBFB,RUVBL2,KAT5,POU2F1,HRK,JUND,JDP2,MAPK14 |
| Adipogenesis | NCOA2,FRZB,NRIP1,AHR,BMP3,CFD,MEF2AA,CNTFR,GDF10,CYP26A1 |
Protein Function
GADD45A has several biochemical functions, for example, core promoter binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GADD45A itself. We selected most functions GADD45A had, and list some proteins which have the same functions with GADD45A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter binding | IFI16,PSPC1,RBMX,CLOCK,AGO2,NPAS2,HDAC5,SFPQ,HDAC1,IRF9 |
| protein binding | RPS3,NEIL2,DYNLT3,GRAP2,SSX5,PRKAA2,CCDC103,TSPAN1,TP53BP1,ZNF703 |
Interacting Protein
GADD45A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GADD45A here. Most of them are supplied by our site. Hope this information will be useful for your research of GADD45A.
GADD45GIP1;MAP2K6;DCTN2;TDG;NUCB2;SH3GLB1;AICDA;GADD45GIP1
GADD45A Related Signal Pathway
Resources
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References
- Addinsell, C; Walmsley, R; et al. Polyphenolic antioxidants that produce positive results in the GADD45a-GFP assay reduce levels of oxidised DNA tested using 8OxodG antibody. MUTAGENESIS 29:544-545(2014).
- Dong, YL; Kabir, SM; et al. CXCR2-Driven Ovarian Cancer Progression Involves Upregulation of Proinflammatory Chemokines by Potentiating NF-kappa B Activation via EGFR-Transactivated Akt Signaling. PLOS ONE 8:-(2013).
