Recombinant Human GADD45A, His-tagged

• Cat.No.: GADD45A-26075TH
• Product Overview: Recombinant full length Human GADD45A with C terminal His tag; 173 amino acids with tag, MWt 19.4kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Conjugation: HIS
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPERLEHHH HHH
• Sequence Similarities: Belongs to the GADD45 family.
• Full Length: Full L.

Gene Information

• Gene Name: GADD45A growth arrest and DNA-damage-inducible, alpha [ Homo sapiens ]
• Official Symbol: GADD45A
• Synonyms: GADD45A; growth arrest and DNA-damage-inducible, alpha; DDIT1; growth arrest and DNA damage-inducible protein GADD45 alpha; GADD45
• Gene ID: 1647
• mRNA Refseq: NM_001199741
• Protein Refseq: NP_001186670
• MIM: 126335
• Uniprot ID: P24522
• Chromosome Location: 1p31.2
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem
• Function: protein binding