Fzd10
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Official Full Name
frizzled class receptor 10 -
Overview
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008] -
Synonyms
FZD10;frizzled class receptor 10;Fz10;FzE7;CD350;FZ-10;hFz10;frizzled-10;frizzled homolog 10;frizzled family receptor 10;frizzled 10, seven transmembrane spanning receptor;Mfz10;Mfz10a;AL033370;AW456835
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Mus musculus
- E.coli
- HEK293
- Mammalian cells
- Human Cell
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Fc
- Non
- C-His&Fc
- His&Fc&Avi
Involved Pathway
Fzd10 involved in several pathways and played different roles in them. We selected most pathways Fzd10 participated on our site, such as Basal cell carcinoma,Class B/2 (Secretin family receptors),GPCR ligand binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Melanogenesis | Kitl,TCF7L2,KITLGB,FZD9B,FZD3,MAPK3,CALM1B,GNAS,FZD3B,WNT5A |
| Class B/2 (Secretin family receptors) | GNB5A,PTH2,RAMP1,CRHB,EMR4,CALCA,CALCRL,PTHLH,RCA2.1,CRH |
| Hippo signaling pathway | RASSF1,TGFBR2,TEAD3,LATS1,DVL3,AREG,AXIN2,JUB,FZD3,PARD6A |
| GPCR ligand binding | EDN2,GPR55A,OPN1LW,SETD6,GNB5A,S1PR5B,CCL27,GPR68,RHOL,PROKR1 |
| Proteoglycans in cancer | RAF1,PIK3CA,HSPB2,ITGB5,ITPR1,WNT2,FZD8,WNT3,SDC1,ACTG1 |
| Basal cell carcinoma | WNT1,BMP4,TRP53,LEF1,BMP2,PTCH1,WNT7A,FZD2,HHIP,TCF7 |
| HTLV-I infection | NFYB,ANAPC1,TLN1,PPP3R2,CD3E,RRAS,PDGFB,NFATC2,PIK3R1,PIK3R5 |
| Pathways in cancer | FN1,MLH1,WNT6,BIRC8,BID,PTGS2,GSTP1,CASP9,MMP1,BIRC7 |
Protein Function
Fzd10 has several biochemical functions, for example, G-protein coupled receptor activity,Wnt-activated receptor activity,Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd10 itself. We selected most functions Fzd10 had, and list some proteins which have the same functions with Fzd10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Wnt-protein binding | CTHRC1,GM12824,PTPRO,Fzd4,SMO,SFRP1,GPR177,LRP5,SZL,FZD3A |
| G-protein coupled receptor activity | COR1,CELSR3,TAS2R118,MRGPRB4,GPR148,APLNR,PROKR2,OLFR24,BAI3,OLFR13 |
| Wnt-activated receptor activity | FZD2,FZD3,FZD8B,FZD6,LRP6,LRP5,FZD3A,FZD7A,LRP5L,FZD5 |
| protein binding | RPS27A,Aatk,TMIGD2,RHOBTB3,SEPT5,PDE1B,EME1,DBNDD2,PKHD1L1,TSPAN4 |
Interacting Protein
Fzd10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd10 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd10.
HILPDA
Fzd10 Related Signal Pathway
Resources
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References
- Gong, C; Qu, SH; et al. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. NATURE COMMUNICATIONS 5:-(2014).
- Sun, Q; Wang, RH; et al. Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/beta-catenin pathway. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1638-1648(2014).
