EPOR
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Official Full Name
Erythropoietin Receptor -
Overview
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. -
Synonyms
EPOR;erythropoietin receptor;EPO-R;MGC138358
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- Dog
- Mus musculus
- HEK293
- Human Cell
- Mammalian cells
- Insect Cell
- Wheat Germ
- Mammalian Cell
- Human
- Insect Cells
- E.coli
- Rabbit
- In Vitro Cell Free System
- E.coli expression system
- His
- Fc
- Non
- His&Fc
- GST
- His&GST
- His&SUMO
- His&Fc&Avi
Involved Pathway
EPOR involved in several pathways and played different roles in them. We selected most pathways EPOR participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | IL28RA,GM13305,PIK3R1,LEPA,PIK3CA,EPO,PTPN2B,AOX1,IL9R,BCL2 |
| Hematopoietic cell lineage | IL11RA2,IL1R1,Flt3l,CD3D,KITLG,CD8B1,IL9R,HLA-DRB3,CD1E,GM2002 |
| PIK-Akt signaling pathway | ITGA6,MDM2,ITGA2B,PRKCA,COL6A5,HGF,SOS1,GNG12,TCL1B1,ANGPT2 |
| Cytokine-cytokine receptor interaction | IL26,ACVR1BA,TGFBR1B,HGF,IFNA16,CCR6,CXCR1,TP-1,BMPR2,OSM |
Protein Function
EPOR has several biochemical functions, for example, erythropoietin receptor activity,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPOR itself. We selected most functions EPOR had, and list some proteins which have the same functions with EPOR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | PFKL,BLOC1S6,PRPF19,ATXN10,SHANK1,BCHE,HOOK2,GRB7,CLDN9,CLDN3 |
| protein binding | CALU,WDR77,RNF220,GPR77,ATRX,WASF1,IGFBP5,KCND3,PRLHR,DDRGK1 |
Interacting Protein
EPOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPOR here. Most of them are supplied by our site. Hope this information will be useful for your research of EPOR.
PTPN6;PTPN1;Cish;INPP5D
EPOR Related Signal Pathway
Resources
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References
- Maxwell, P; Melendez-Rodriguez, F; et al. Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. BRITISH JOURNAL OF HAEMATOLOGY 168:429-442(2015).
- Fujimi, A; Kamihara, Y; et al. Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. INTERNATIONAL JOURNAL OF HEMATOLOGY 100:490-493(2014).
