CYP51A1
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Official Full Name
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 [ Homo sapiens ] -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CP51;CP51A_HUMAN;CYP51;CYP51A1;CYPLI;Cytochrome P450 51;Cytochrome P450 51A1;Cytochrome P450-14DM;Cytochrome P45014DM;Cytochrome P450LI;Lanosterol 14-alpha demethylase;LDM;P450 14DM;P450L1;Sterol 14-alpha demethylase
Recombinant Proteins
- Human
- Chicken
- Bovine
- Rat
- Pongo Abelii
- Mus musculus
- Sus scrofa (Pig)
- Macaca fascicularis
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
CYP51A1 involved in several pathways and played different roles in them. We selected most pathways CYP51A1 participated on our site, such as Activation of gene expression by SREBF (SREBP),Biological oxidations,Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP51A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NDUFB2,FUT1,SPHK2,P4HA1B,COX4I1,NDUFA5,MTHFS,ITGB1BP3,AMPD2,AKR1C4 |
| Activation of gene expression by SREBF (SREBP) | HELZ2,CARM1,DHCR7,NFYBB,MTF1,NCOA2,PMVK,NFYBA,CREBBP,SREBF2 |
| Endogenous sterols | CYP19A1,CYP11B1,CYP11A1,CYP27A1,FDXR,FDX1L,CYP21A2,CYP17A1,CYP11B2,FDX1 |
| Biological oxidations | ACY3.2,UGT1B2,Sult2a6,SULT1ST5,CYP11A1,AADAC,SLC26A2,CYP2J2,SULT2ST1,ACY3.1 |
| Cholesterol biosynthesis | ARV1,SREBF2,EBP,PMVK,DHCR7,LBR,DHCR24 |
| Metabolism | SLC25A13,COQ7,CYP2C18,CERS3B,APOEB,DTYMK,GPAT2,ISCU,NDUFS7,AKR1C6 |
| Cytochrome P450 - arranged by substrate type | CYP19A1,CYP3A4,CYP17A1,CYP2AD3,CYP3A7,CYP11B2,CYP2B6,CYP2K19,CYP2U1,CYP2A13 |
| Biosynthesis of antibiotics | SDS,DLST,DLD,BPNT1,ECHS1,GLYCTK,LDHAL6A,ADH5,CMBL,GALM |
Protein Function
CYP51A1 has several biochemical functions, for example, heme binding,iron ion binding,sterol 14-demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP51A1 itself. We selected most functions CYP51A1 had, and list some proteins which have the same functions with CYP51A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP2C50,EGLN1,PLOD1A,CYP2AD3,ISCUB,C14orf169,CYP2AA7,CYP2E1,CYP2P9,CYP3A25 |
| heme binding | CYP2B6,CYBA,CYP3A25,CYP3C4,NR1D1,CYP2D6,CYP2E1,CYP2H1,CYP2J6,CYB5D2 |
| sterol 14-demethylase activity | CYP51 |
Interacting Protein
CYP51A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP51A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP51A1.
ETS1;ZNF420;1C
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