CX3CR1
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Official Full Name
chemokine (C-X3-C motif) receptor 1 -
Overview
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] -
Synonyms
CX3CR1;chemokine (C-X3-C motif) receptor 1;V28;CCRL1;GPR13;CMKDR1;GPRV28;CMKBRL1;CX3C chemokine receptor 1;CMK-BRL1;CMK-BRL-1;C-X3-C CKR-1;fractalkine receptor;G protein-coupled receptor 13;G-protein coupled receptor 13;chemokine (C-X3-C) receptor 1;beta chemokine receptor-like 1;chemokine (C-C) receptor-like 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Bovine
- HEK293
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- Non
- His
- GST
- His&Fc&Avi
- His&GST
Involved Pathway
CX3CR1 involved in several pathways and played different roles in them. We selected most pathways CX3CR1 participated on our site, such as Chemokine receptors bind chemokines,Chemokine signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide GPCRs | SSTR4,SSTR5,TAC4,CXCR6,SSTR1 |
| Chemokine signaling pathway | CCL28,BRAF,NRAS,CCL25,WAS,CXCL5,CCL20,ADRBK1,PAK1,VAV3 |
| GPCR ligand binding | ADM2,GRP,EDN3,EMR4,OXGR1,RAMP2,OPN1LW,AMCF-II,OPN4A,ADORA1 |
| GPCRs, Class A Rhodopsin-like | GPR20,GPR39,CCR9,CMKLR1,OPN1SW,GPR1,ADORA1,GPR32,GPR6,NPFFR2 |
| Peptide ligand-binding receptors | GPR37B,HCRT,NPFF,NPSR1,SST,ACKR4,NMS,NMBA,ZFPM2B,EDNRAB |
| Class A/1 (Rhodopsin-like receptors) | TAC1,KEL,ACKR4,RXFP2,TAAR1,NMU,ADRA2B,TRH,S1PR3,NMS |
| Chemokine receptors bind chemokines | CXCL13,CCL35.2,CCL27,CXCL11.8,CCRL2,CCBP2,AMCF-II,CCR7,CCR6,CCR5 |
| Cytokine-cytokine receptor interaction | Kitl,CRFB16,IFNPHI3,CCL27B,IL18R1,IL-8,IL3,IL12A,TNFSF14,CXCR4 |
Protein Function
CX3CR1 has several biochemical functions, for example, C-X3-C chemokine receptor activity,chemokine receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CR1 itself. We selected most functions CX3CR1 had, and list some proteins which have the same functions with CX3CR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FASTKD3,OTUD7B,IST1,THBD,HSPA1B,DEPDC6,TMA16,STX16,PPP1R12B,GTF2F1 |
| chemokine receptor activity | CMKLR1,CCRL2,RGRB,CCR8,XCR1,GPR17,CCR6A,CXCR3,PRLH2R,CCR6 |
Interacting Protein
CX3CR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CR1.
Resources
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References
- Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
- Bian, C; Zhao, ZQ; et al. Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation. PLOS ONE 10:-(2015).
