CDH1
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Official Full Name
cadherin 1, type 1, E-cadherin (epithelial) -
Overview
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. -
Synonyms
CDH1;cadherin 1, type 1, E-cadherin (epithelial);UVO;CDHE;ECAD;LCAM;Arc-1;CD324;cadherin-1;CAM 120/80;E-Cadherin;uvomorulin;cell-CAM 120/80;epithelial cadherin;cadherin 1, E-cadherin (epithelial);calcium-dependent adhesion protein, epithelial;Arc1;CADH1_HUMAN;Cadherin 1;cadherin 1 type 1 E-cadherin;Cadherin1;CD 234;CD324 antigen;E-Cad/CTF3;epithelial calcium dependant adhesion protein;Liver cell adhesion molecule
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Rhesus macaque
- Chicken
- Pig
- Zebrafish
- Xenopus laevis
- Mus musculus
- HEK293
- Human Cells
- E.coli
- Mammalian Cells
- C-His
- Wheat Germ
- Insect Cells
- In Vitro Cell Free System
- Fc
- His
- Non
- GST
- hIgG4
- Strep II
- His&S
- GST&His
- Flag
- Avi&Fc&His
- DDK&Myc
Involved Pathway
CDH1 involved in several pathways and played different roles in them. We selected most pathways CDH1 participated on our site, such as Rap signaling pathway,Hippo signaling pathway,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | SOX2,AREG,FZD9,CCND2,PPP2R2D,TEAD4,LATS2,SMAD3,WNT8B,FZD3 |
| Bacterial invasion of epithelial cells | WASL,ARPC5L,ARPC1A,PIK3CD,ILK,SHC3,WAS,SHC1,CAV1,DNM3 |
| Adherens junction | LMO7,FGFR1,EGFR,ACTN3,IGF1R,PVRL3,MLLT4,WASB,TCF7L1A,WASLB |
| Endometrial cancer | ILK,CTNNA2,PDPK1,SOS1,PIK3CG,MLH1,PIK3R2,PIK3R3,APC2,ELK1 |
| Bladder cancer | MAPK3,DAPK2,IL-8,HBEGF,MYC,RAF1,SRC,RPS6KA5,RB1,CCND1 |
| Pathogenic Escherichia coli infection | TLR5,ARPC5L,TUBB,TUBA1A,NCK1,CDC42,TUBA1C,KRT18,ARHGEF2,TUBA8 |
| Thyroid cancer | CCDC6,TCF7L2,KRAS,PAX8,TFG,TPM3,TCF7,MAP2K1,MAP2K2,NRAS |
| Pathways in cancer | PIK3R2,FLT3,STK4,PTGER4,CCNA1,FGF6,AGTR1B,GNAQ,BIRC8,NCOA4 |
| Melanoma | CCND1,BRAF,FGF14,RAF1,BAD,FGF2,FGF17,TRP53,MAP2K2,Fgf15 |
Protein Function
CDH1 has several biochemical functions, for example, GTPase activating protein binding,ankyrin binding,beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH1 itself. We selected most functions CDH1 had, and list some proteins which have the same functions with CDH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | TFR2,ERBB2,ACE2,B2M,ITGA3,FBXO2,CD4,VIM,ITGB2,TFRC |
| cell adhesion molecule binding | NLGN4Y,ITGA4,DSP,PVRL4,CADM1B,Fert2,CADM1,PTBP3,PVRL1,CADM1A |
| calcium ion binding | MATN2,SLC25A23,MMP3,C2CD4B,DHH,PGS1,S100A4,CIB3,PCDH2AB12,MBL2 |
| GTPase activating protein binding | PLCD1,TUBB,FMNL1,PIN1,RGS14,MEX3B,PTBP3,TSC1,GNAO1,GNAI1 |
| gamma-catenin binding | CDH2,LEF1,APC,CTNNA1,TCF7L2,FER,APC2,Fert2,PTPRK,PTPRJ |
| ankyrin binding | KCNQ2,SCN5A,KCNJ11,ATP1A1,SPTBN1,PLEC,OBSCN,RHCG,KCTD6,NRCAM |
| protein binding | SRSF11,TYROBP,EXOSC8,ATP4B,ZNF550,ZMYND19,LRP2BP,TUB,GNB5,GIMAP7 |
| beta-catenin binding | TCF7L1A,BCL9L,VCL,ASH2L,DACT3,SALL1,GRIP1,PXN,PTPRJ,KLF4 |
Interacting Protein
CDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH1.
CTNNB1;EGFR;Cbll1
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References
- Waldum, HL; Ringnes, E; et al. The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 49:974-978(2014).
- Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).
