Recombinant Human CDH1 Protein, C-8His tagged, Biotinylated

• Cat.No.: CDH1-41H
• Product Overview: Biotinylated Recombinant Human Cadherin-1 is produced by Human 293 Cells. The target gene encoding Q23-A709 is expressed with a 8His tag at the C terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: Q23-A709
• Description: E-Cadherin is a calcium-dependent cell adhesion glycoprotein that belongs to the cadherin family. E-Cadherin is expressed in non-neural epithelial tissues. It tends to interact with each other in a homophilic manner in connecting cells. E-Cadherin clusters are critical components of adherent junctions between epithelial cells and act in the formation and maintenance of the epithelial cell barrier. E-Cadherin is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. E-Cadherin loss contributes to cancer metastasis. The extracellular E-Cadherin N-terminal domain can be cleaved by several proteases and is released as a soluble factor that enhances cancer cell motility and EGFR-dependent survival and proliferation.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.2
• Shipping: Ambient

Gene Information

• Gene Name: CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens (human) ]
• Official Symbol: CDH1
• Synonyms: Cadherin-1; CDH1; CAM 120/80; E-cadherin; CD324
• Gene ID: 999
• mRNA Refseq: NM_004360
• Protein Refseq: NP_004351
• MIM: 192090
• UniProt ID: P12830