Casp3
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Official Full Name
caspase 3, apoptosis-related cysteine peptidase -
Overview
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. -
Synonyms
CASP3;caspase 3, apoptosis-related cysteine peptidase;CPP32;SCA-1;CPP32B;Apopain;CPP-32;EC 3.4.22.56;Yama;procaspase3;Cysteine protease CPP32;PARP cleavage protease;SREBP cleavage activity 1;Yama protein;caspase 3, apoptosis-related cysteine protease
Recombinant Proteins
- Cynomolgus
- Human
- Mouse
- Rat
- Chicken
- Cattle
- E.coli
- Insect cells
- Wheat Germ
- Mammalian Cells
- Human Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&MBP
- His&T7
- His&Strep
- Avi&Fc&His
- DDK&Myc
- Flag
Involved Pathway
Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway,p signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toxoplasmosis | NFKBIB,IL12A,TGFB3,PDPK1,GNAI2,PIK3R5,TGFB1,MYD88,IFNGR2,BAD |
| MicroRNAs in cancer | CDC25B,BMI1,RAF1,APC2,ERBB2,PTEN,ABL1,DICER1,PDGFB,PRKCA |
| Amoebiasis | ACTN1,IFNG,SERPINB1C,C8A,LAMA2,LAMA1,ITGAM,CD1D,COL2A1,LAMC3 |
| MAPK signaling pathway | MAP3K12,FGF10,DUSP16,TAOK1,RPS6KAL,AKT2L,NRAS,TGFBR1A,TGFBR2,CACNB3 |
| Parkinsons disease | NDUFA4L2,CYCS,NDUFC1,ATP5C1,NDUFA10,SDHB,CASP9,ATP5O,PRKACG,SLC18A1 |
| Amyotrophic lateral sclerosis (ALS) | NEFH,BCL2,DAXX,SOD1,NEFL,PPP3R1,APAF1,CAT,MAPK13,CYCS |
| Legionellosis | IL-8,SEC22B,TLR5,CLK1,HSPA6,CASP7,Itgam&Itgb2,NAIP7,HBS1L,NAIP6 |
| Herpes simplex infection | IKBKG,POU2F3,CUL1B,IKBKE,PILRA,PPP1CAA,HLA-DQB1,EIF2AK3,OAS3,FASLG |
| p signaling pathway | STEAP3,CCND1,CASP9,LRDD,APAF1,THBS1,TSC2,PTENB,PPM1DB,TP53 |
Protein Function
Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity,cyclin-dependent protein serine/threonine kinase inhibitor activity,cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type peptidase activity | CTSL1B,CASP3A,CAPN3A,USP43A,CAPN1A,CTSC,CTSSB.1,PIGK,CTSLA,PGPEP1 |
| cysteine-type endopeptidase activity | CTS7,USP49,USP44,PSD,CTSC,USP6,CTSF,CASP3B,MALT1,USP47 |
| phospholipase A2 activator activity | PLAA |
| peptidase activity | GM5136,Acr,TMPRSS5,KLK1B1,CTSG,FURINB,ESPL1,CAPN3,MEP1A.1,CAPN2B |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | CDKN2C,CDKN1BB,CDKN1BA,HEXIM1,CDKN1A,CDKN1C,CDKN2D,CDKN1D,CDKN2B,HEXIM2 |
| aspartic-type endopeptidase activity | SPPL2,PGA,SPPL3,PGA5,BACE2,DDI2,DDI1,Ren1,ANK2B,PGA4 |
| cysteine-type endopeptidase activity involved in apoptotic process | CLC,CASP8 |
| protease binding | HSPD1,TIMP2B,DPP4,TNFRSF10A,VWF,TRP53,FN1,INSL3,FAP,ALPI |
| protein binding | 2610109H07Rik,CNOT4,SBNO2,LENG1,ZCCHC10,AEN,TAF11,TAF9B,ARIH1,GPR177 |
Interacting Protein
Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.
THAP11;Parp1;Hdgf;Pkm;Rps18;Acta2;Fam21;Nucks1;Htt
Casp3 Related Signal Pathway
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References
- Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
- Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Reviews
The rat caspase3 worked/is working very well for us.
