Recombinant Human CAMK2A Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CAMK2A-6286H
• Product Overview: CAMK2A MS Standard C13 and N15-labeled recombinant protein (NP_741960) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene.
• Molecular Mass: 54.1 kDa
• AA Sequence: MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPHTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CAMK2A calcium/calmodulin-dependent protein kinase II alpha [ Homo sapiens (human) ]
• Official Symbol: CAMK2A
• Synonyms: CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin dependent protein kinase (CaM kinase) II alpha, CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; calcium/calmodulin dependent protein kinase II alpha B subunit; calcium/calmodulin dependent protein kinase type II alpha chain; CaM kinase II alpha subunit; CaM kinase II alpha chain; CaMK II alpha subunit; CaMKIINalpha; KIAA0968; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; CAMKA
• Gene ID: 815
• mRNA Refseq: NM_171825
• Protein Refseq: NP_741960
• MIM: 114078
• UniProt ID: Q9UQM7