ASGR2
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Official Full Name
asialoglycoprotein receptor 2 -
Overview
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
ASGR2;asialoglycoprotein receptor 2;CLEC4H2;ASGP R;ASGP-R 2;ASGPR 2;ASGPR2;ASGR2_HUMAN;C type lectin domain family 4 member H2;C-type lectin domain family 4 member H2;Hepatic lectin 2;Hepatic lectin H2;Hepatic lectin R2/3;HL-2;Hs.1259;L H2;LH2;MGC108546;MHL 2;RHL2;OTTHUMP00000128352;OTTHUMP00000128353;HBxAg-binding protein;HBXBP;ASGP-R2
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- HEK293
- E.coli
- Mammalian cells
- Wheat Germ
- Mammalian Cell
- Human Cell
- In Vitro Cell Free System
- In vitro E. coli expression system
- HEK293T
- E.coli expression system
- His
- GST
- Non
- His&Myc
- His&Myc&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ASGR2 involved in several pathways and played different roles in them. We selected most pathways ASGR2 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | PAX8,CREB3L2,ATP1B4,DUOX2,GNAS,PRKCA,GPX6,TSHB,PRKACG,FXYD2 |
Protein Function
ASGR2 has several biochemical functions, for example, asialoglycoprotein receptor activity,carbohydrate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASGR2 itself. We selected most functions ASGR2 had, and list some proteins which have the same functions with ASGR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| asialoglycoprotein receptor activity | LRPAP1,ASGR1 |
| carbohydrate binding | CD209,FCER2,KLRD1,HBL4,CHI3L1,KLRK1,CLEC4D,MBL1,CLC,GANAB |
| protein binding | LDHAL6B,CIB3,UBE2D4,EIF2S1,PEX1,TFDP1,UPK3A,CD5,MAB21L3,MAVS |
Interacting Protein
ASGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASGR2.
CERS2;GLUD1;HES1;q6zmw9_human
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References
- Choi, J; Jeong, JM; et al. Ga-68-labeled neolactosylated human serum albumin (LSA) for PET imaging of hepatic asialoglycoprotein receptor. NUCLEAR MEDICINE AND BIOLOGY 42:53-58(2015).
- Kanno, Y; Watanabe, H; et al. Anti-phosphoenolpyruvate carboxykinase 2 antibody in patients with autoimmune hepatitis. HEPATOLOGY RESEARCH 44:1019-1025(2014).
