ANXA5
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Official Full Name
annexin A5 -
Overview
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some;of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a;phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in;cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental;anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin;CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein;product with a molecular weight of about 35 kDa. -
Synonyms
ANXA5;annexin A5;ANX5, ENX2;CBP-I;PAP-I;VAC-alpha;annexin V;annexin-5;anchorin CII;endonexin II;lipocortin V;calphobindin I;thromboplastin inhibitor;vascular anticoagulant-alpha;placental anticoagulant protein 4;placental anticoagulant prot
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Rat
- Hamster
- Cynops pyrrhogaster
- E.coli
- Yeast
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- CHO
- In Vitro Cell Free System
- HEK293F
- E. coli
- HEK293T
- His
- GST
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ANXA5 involved in several pathways and played different roles in them. We selected most pathways ANXA5 participated on our site, such as Prostaglandin Synthesis and Regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostaglandin Synthesis and Regulation | ANXA4,ANXA3,S100A6,ANXA2,ANXA6,CC10,S100A10 |
Protein Function
ANXA5 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipid binding,peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA5 itself. We selected most functions ANXA5 had, and list some proteins which have the same functions with ANXA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent phospholipid binding | SYT1A,ANXA5B,RPH3AL,ANXA5A,ANXA8,ANXA1B,SYT9B,ANXA10,AP1S2,SYT10 |
| peptide hormone binding | RXFP2,PTH1RA,MAS1,PTH1R,PTH1RB,EDNRB,NPR1,AGTR2,GIPR,MC3R |
| phospholipase inhibitor activity | ANXA3A,SNCB,APOC1,ANXA1B,ANXA2B,ANXA4,ANXA1A,ANXA2A,ANXA3B,ANXA1C |
| receptor tyrosine kinase binding | TRP53,CPNE3,SHC3,HYAL2,Flt3l,PTPN14,NCK1,NRG1,GAS6,MYOC |
| calcium ion binding | CD93,ARSA,SRR,NUCB2B,NOTCH1B,EFCAB5,MMP8,PDCD6,AKR1C1,PCDHB10 |
| protein binding | CDK1,PPP1R16A,RAB26,GH1,CENPA,HMGB3,RAB22A,G6PD,LILRB2,ATP6V1F |
| phospholipid binding | APOA2,DGKA,SMURF1,NUP35,AGAP1,PICALMB,APOM,SYT14,OTC,NBEAA |
Interacting Protein
ANXA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA5.
TINF2;Eif5b;Atrx;Bod1l1;Pds5a;Bles03;Dnmt1;yopM;FDFT1;TERF1;SUPT4H1;EIF4G1;TERF2;ispH;trmFO;TERF2IP;LAMC3;polg_hcvjf_rna
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References
- Rogenhofer, N; Engels, L; et al. Lower Incidence of M2/ANXA5 Carriage in Recurrent Pregnancy Loss Patients With Elevated Lipoprotein(a) Levels. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 20:706-709(2014).
- Haeckel, A; Appler, F; et al. XTEN-Annexin A5: XTEN Allows Complete Expression of Long-Circulating Protein-Based Imaging Probes as Recombinant Alternative to PEGylation. JOURNAL OF NUCLEAR MEDICINE 55:508-514(2014).
