VRK1
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Official Full Name
vaccinia related kinase 1 -
Overview
The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome. This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 (1-3). The VRK1 has autophosphorylation activity and phosphorylates several trans -
Synonyms
VRK1;vaccinia related kinase 1;serine/threonine-protein kinase VRK1;vaccinia-related kinase 1;vaccinia virus B1R-related kinase 1;PCH1;MGC117401;MGC138280;MGC142070
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cell
- E. coli
- Insect Cells
- Yeast
- HEK293
- His
- GST
- His&GST
- Non
- Flag
- His&Myc
- His&Fc&Avi
Involved Pathway
VRK1 involved in several pathways and played different roles in them. We selected most pathways VRK1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Clearance of Nuclear Envelope Membranes from Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with VRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitotic Prophase | ENSA,ARPP19B,SMC2,NEK9,VRK2,SMC4,ARPP19,MASTL,BLZF1,NCAPG2 |
| Cell Cycle, Mitotic | PDS5B,PHF8,FGFR1OP,TUBG2,LEMD3,TUBGCP4,CEP152,CENPE,CEP290,MAPRE1B |
| Initiation of Nuclear Envelope Reformation | TMPO,ANKLE2,LEMD3,VRK2 |
| Mitotic Anaphase | CCDC99,NSL1,SPDL1,NDEL1,NDEL1B,PMF1,CENPK,NUDC,ITGB3BP,CDCA5 |
| Mitotic Metaphase and Anaphase | SGOL2,ZW10,CENPH,NSL1,SPC24,CDCA8,PDS5A,SKA1,TMPO,NDEL1B |
| Cell cycle | ANAPC4,CENPK,MYBL2,CCNB3,TUBG2,CLASP1A,APITD1,EP300,CENPW,MPEG1 |
| M Phase | CENPQ,SET,ZW10,TMEM188,APITD1,PDS5B,CENPA,ERCC6L,DULLARD,CENPK |
| Clearance of Nuclear Envelope Membranes from Chromatin | TMPO,BANF1,LEMD3,VRK2 |
Protein Function
VRK1 has several biochemical functions, for example, ATP binding,histone kinase activity (H3-S10 specific),histone kinase activity (H3-T3 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by VRK1 itself. We selected most functions VRK1 had, and list some proteins which have the same functions with VRK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZMAT4,RPS6KA3,ERCC6,PPP3CB,ANTXR2,FOS,DNAJA2,PSMB7,TNFAIP8L2,CHRM3 |
| nucleosomal histone binding | L3MBTL1,UHRF1 |
| histone kinase activity (H3-S10 specific) | RPS6KA5,RPS6KA4 |
| protein kinase binding | MSN,NME2,CDH2,SOCS1,BCL2L1,PPP1R12C,ACSL3,SUFU,CDKN2B,EPHA1 |
| ATP binding | GARS,ABCG2A,AK8,VPS4A,RARS,MYO6B,CAMK1DB,DAPK2A,DDX46,PFTK1 |
| protein serine/threonine kinase activity | PRKCD,CDK11B,ZAK,NUAK1,MAP2K1,GM7168,ACVR1L,TTN,PBK,ILK |
| histone kinase activity (H3-T3 specific) | GSG2 |
| protein kinase activity | WNK2,DCLK2,EEF2K,PRKCD,ARAF,NPR1A,CCL5,LMTK3,FYNB,ACVR1 |
Interacting Protein
VRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VRK1.
atp;N/A;COIL
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References
- Kim, W; Lyu, HN; et al. Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer. MOLECULAR PHARMACOLOGY 83:367-376(2013).
- Valbuena, A; Lopez-Sanchez, I; et al. Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 465:219-226(2007).
