Recombinant Human VRK1 Protein (Full Length), N-FLAG tagged

• Cat.No.: VRK1-05H
• Product Overview: Recombinant human VRK1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_003375.1) with a N-terminal FLAG tag.

Specification

• Description: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
• Source: Baculovirus
• Species: Human
• Tag: Flag
• Molecular Mass: 46.7 kDa
• Protein length: Full Length
• Purity: > 90%
• Notes: This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Gene Information

• Gene Name: VRK1 VRK serine/threonine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: VRK1
• Synonyms: VRK1; VRK serine/threonine kinase 1; PCH1; PCH1A; serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; EC 2.7.11.1
• Gene ID: 7443
• mRNA Refseq: NM_003384
• Protein Refseq: NP_003375
• MIM: 602168
• UniProt ID: Q99986