Spint2
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Official Full Name
serine peptidase inhibitor, Kunitz type, 2 -
Overview
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] -
Synonyms
SPINT2;serine peptidase inhibitor, Kunitz type, 2;PB;Kop;HAI2;DIAR3;HAI-2;kunitz-type protease inhibitor 2;placental bikunin;serine protease inhibitor, Kunitz type, 2;hepatocyte growth factor activator inhibitor type 2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian cells
- Mammalian Cell
- Insect Cell
- Human Cell
- E.coli expression system
- HEK293T
- GST
- Fc
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
Spint2 involved in several pathways and played different roles in them. We selected most pathways Spint2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Spint2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
Spint2 has several biochemical functions, for example, endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Spint2 itself. We selected most functions Spint2 had, and list some proteins which have the same functions with Spint2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | SPINK1,AHSG,PI3,UCHL5,PZP,Cstb,CAST,Serpina1b,SERPINA1D,USP14 |
| serine-type endopeptidase inhibitor activity | MUG2,SPINK7,KAL1,SERPINB4,SPINT4,SERPINE1,A2M,SERPINA3K,TFPI,APLP2 |
Interacting Protein
Spint2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Spint2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Spint2.
orf3_hevbu;orf3_hevme;ILK
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References
- Kanekiyo, S; Iizuka, N; et al. Preoperative Serum Methylation Signature as Prognostic Tool After Curative Hepatectomy in Patients with Hepatocellular Carcinoma. ANTICANCER RESEARCH 35:997-1007(2015).
- Brito, MV; de Oliveira, C; et al. The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models. THROMBOSIS RESEARCH 133:945-951(2014).
