Recombinant Human serine peptidase inhibitor, Kunitz type, 2, His-tagged

• Cat.No.: SPINT2-384H
• Product Overview: SPINT2, 28-197aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 28-197 a.a.
• Description: SPINT2 is a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This protein is a putative tumor suppressor, and mutations in this protein result in congenital sodium diarrhea. Recombinant human SPINT2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea 10% glycerol
• Molecular Mass: 21.8 kDa (195aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMADRER SIHDFCLVSK VVGRCRASMP RWWYNVTDGS CQLFVYGGCD GNSNNYLTKE ECLKKCATVT ENATGDLATS RNAADSSVPS APRRQDSEDH SSDMFNYEEY CTANAVTGPC RASFPRWYFD VERNSCNNFI YGGCRGNKNS YRSEEACMLR CFRQQENPPL PLGSK
• Purity: : >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SPINT2 serine peptidase inhibitor, Kunitz type, 2 [ Homo sapiens ]
• Official Symbol: SPINT2
• Synonyms: SPINT2; serine peptidase inhibitor, Kunitz type, 2; serine protease inhibitor, Kunitz type, 2; kunitz-type protease inhibitor 2; HAI 2; Kop; placental bikunin; hepatocyte growth factor activator inhibitor type 2; PB; HAI2; DIAR3; HAI-2; FLJ45571
• Gene ID: 10653
• mRNA Refseq: NM_001166103
• Protein Refseq: NP_001159575
• MIM: 605124
• UniProt ID: O43291
• Chromosome Location: 19q13.2
• Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity