Selplg
-
Official Full Name
selectin P ligand -
Overview
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] -
Synonyms
SELPLG;selectin P ligand;CLA;CD162;PSGL1;PSGL-1;P-selectin glycoprotein ligand 1;cutaneous lymphocyte-associated associated antigen
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rat
- Zebrafish
- E.coli
- HEK293
- CHO
- C-His
- Mammalian cells
- Human Cell
- Mammalian Cell
- His&GST
- C-His&hFc
- His&Fc
- Fc
- Non
- His
- His&T7
- His&Avi
- His&Fc&Avi
Involved Pathway
Selplg involved in several pathways and played different roles in them. We selected most pathways Selplg participated on our site, such as Cell adhesion molecules (CAMs),Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Selplg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CDH2,CD8B,CLDNF,CADM1A,PVR,CLDNC,NLGN2B,NRXN3A,CD58,HLA-DOA |
| Staphylococcus aureus infection | FCAR,FCGR3A,C3,HLA-DRB4,ITGAM,FCGR2B,C5,H2-AB1,MASP1,FCGR2C |
Protein Function
Selplg has several biochemical functions, for example, protein binding,receptor binding,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Selplg itself. We selected most functions Selplg had, and list some proteins which have the same functions with Selplg. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | CTNND1,MTSS1,CD276,Itga10&Itgb1,SERPINE1,SSTR3,FGF18A,CXADR,CROT,PGR |
| virus receptor activity | SERPINB4,MRC1,CLEC5A,CD209,SLC1A5,ITGB7,LDLR,SLAMF1,IDE,GYPA |
| protein binding | TCEANC,UBASH3A,RAP1B,USP46,ELK1,CXCL9,C9orf43,RITA1,ARF5,RPAP3 |
Interacting Protein
Selplg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Selplg here. Most of them are supplied by our site. Hope this information will be useful for your research of Selplg.
SNX20;FLOT2;SELP;o68791_yerpe;sdhA;dcyD;ywdH
Resources
Research Area
Granulocyte MarkersB Cell Chemotaxis, Migration, and Adhesion
T Cell Migration
CD Antigen (Granulocyte Markers)
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
CD Antigen (T Cell Migration/Adhesion)
Monocyte Markers
MDSC Phenotyping - Positive Markers
Related Services
Related Products
References
