Recombinant Human SELPLG Protein (Leu18-Cys320), C-6×His-tagged

Description :	This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Source :	HEK293
Species :	Human
Tag :	His
Form :	Lyophilized
Molecular Mass :	31.4 kDa
Protein length :	Leu18-Cys320
Purity :	> 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage :	Store at -80 centigrade for 12 months (Avoid repeated freezing and thawing)
Storage Buffer :	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 105 % trehalose is added as protectants before lyophilization.

Gene Name	SELPLG selectin P ligand [ Homo sapiens (human) ]
Official Symbol	SELPLG
Synonyms	SELPLG; selectin P ligand; P-selectin glycoprotein ligand 1; CD162; PSGL 1; cutaneous lymphocyte-associated associated antigen; CLA; PSGL1; PSGL-1;
Gene ID	6404
mRNA Refseq	NM_001206609
Protein Refseq	NP_001193538
MIM	600738
UniProt ID	Q14242