SYK
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Official Full Name
spleen tyrosine kinase -
Overview
Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays a central role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. Syk is activated upon binding to immunoreceptor t -
Synonyms
SYK;spleen tyrosine kinase;tyrosine-protein kinase SYK;p72-Syk;FLJ25043;FLJ37489;DKFZp313N1010
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Sf9 Cells
- Mammalian Cells
- Insect Cells
- HEK293
- Insect cells
- Sf21 Cells
- His
- GST
- Non
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
SYK involved in several pathways and played different roles in them. We selected most pathways SYK participated on our site, such as NF-kappa B signaling pathway,Phospholipase D signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | ITGAL,HSPA1L,EIF2AK3,Fcer2a,TRAF3,DDX58,PSMC3,NUP214,POLR2E,HLA-DRA |
| Fc epsilon RI signaling pathway | MAPK10,GM-CSF,MAP2K2,IL3,PLCG1,MAPK8,LAT,RAF1,NRAS,MAP2K1 |
| Osteoclast differentiation | FCGR1,LILRA5,STAT1,LILRA2,SIRP-BETA,MAP3K14,IKBKB,MAPK11,FCGR3A,CAMK4 |
| NF-kappa B signaling pathway | IL-8,CCL13,ERC1,Ccl21c,MAP3K14,LY96,IKBKB,TNFSF11,TNFSF13B,TRAF3 |
| Fc gamma R-mediated phagocytosis | FCGR2B,PRKCE,GAB2,WASL,cgr2b,VAV2,PIK3R1,PIK3R2,PPAP2C,PPAP2B |
| B Cell Receptor Signaling Pathway | NFATC2,VAV2,AKT2,BCL2L11,DUSP4,CDK6,PLEKHA1,INPP5D,SOS1,RAC1 |
| Natural killer cell mediated cytotoxicity | KIR2DL4,MAPK3,Fasl,NCR2,ULBP3,ITGB2L,IFNA7,IFNA13,HLA-C,SHC1 |
| Platelet activation | GUCY1B3,ARHGAP35,PTGS1,GNAI1,PRKG2,PIK3R2,SNAP23,FCGR2A,PLA2G4D,PIK3CD |
| Phospholipase D signaling pathway | MRAS,PDGFRB,HRAS,GNAS,AKT1,PTPN11,SOS1,GRM3,INS2,DGKZ |
Protein Function
SYK has several biochemical functions, for example, ATP binding,integrin binding,non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYK itself. We selected most functions SYK had, and list some proteins which have the same functions with SYK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | ALK,FGFR4,INSRB,TTN,NTRK2B,FER,FYNB,PTK2BB,FGR,CLK4 |
| non-membrane spanning protein tyrosine kinase activity | FGR,YRK,SRC,BAZ1B,BTK,FER,TYK2,ABL2,TNK1,ZNF143B |
| receptor signaling protein tyrosine kinase activity | KITA,ERBB2,ERBB4A,EGFRA,TYRO3,INSR,LYN,EGFR,KITB,KIT |
| protein kinase binding | PRDX3,TBC1D14,NSF,ILK,PTEN,CCNE2,TICAM1,TRAF4,RPTOR,SPDYE2 |
| ATP binding | SYN3,AGAP2,MAPKAPK2B,ATP13A1,INSR,ABCB8,NLRP9C,IKBKB,PGK2,MYH3 |
| protein binding | RARRES2,GIPC2,EIF2A,CBLL1,EIF2AK3,OSBPL3,MKNK1,NAE1,ADAM23,CSGALNACT2 |
| integrin binding | DMP1,ITGA6,ITGA3,ICAM2,IGF1,CALR,FN1A,ITGB5,ADAM15,FERMT3 |
| protein kinase activity | CSNK1G3,CSF1RA,CCL3,AKT3A,CAMK2B1,CCL5,HIPK3A,KSR1,GM4922,SNRKB |
| protein serine/threonine kinase activity | IKBKB,SIK2A,PIK3R4,RIPK3,ADCK1,MAP3K2,SRPK1A,AKT2,PAK2B,TAF1 |
Interacting Protein
SYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYK here. Most of them are supplied by our site. Hope this information will be useful for your research of SYK.
LCK;CBL;STAT3;USP25
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References
- Chandran, SR; Tesch, GH; et al. Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 96:54-62(2015).
- Khairnar, V; Duhan, V; et al. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. NATURE COMMUNICATIONS 6:-(2015).
