Recombinant Human SYK

• Cat.No.: SYK-31488TH
• Product Overview: Recombinant full length Syk protein (Human), was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, MW 100 kDa.

Specification

• Description: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.Contains 1 protein kinase domain.Contains 2 SH2 domains.
• Tag: Non
• Full Length: Full L.

Gene Information

• Gene Name: SYK spleen tyrosine kinase [ Homo sapiens ]
• Official Symbol: SYK
• Synonyms: SYK; spleen tyrosine kinase; tyrosine-protein kinase SYK
• Gene ID: 6850
• mRNA Refseq: NM_001135052
• Protein Refseq: NP_001128524
• MIM: 600085
• Uniprot ID: P43405
• Chromosome Location: 9q22
• Pathway: Alpha-synuclein signaling, organism-specific biosystem; Atypical NF-kappaB pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem
• Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding