Recombinant Human Spleen Tyrosine Kinase, GST-tagged, Active

• Cat.No.: SYK-439H
• Product Overview: Recombinant full-length human SYK was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 100 kDa.

Specification

• Cat. No.: SYK-439H
• Description: SYK is a non-receptor protein tyrosine kinase that is widely expressed in hematopoietic cells. It is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. In B cells, SYK plays a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement. SYK has been shown to act as a potential tumor suppressor in breast cancer. Absence of SYK protein in primary breast tumors is correlated with poor outcomes. SYK deficient cells have increased motility that is restored to normalcy by replacement with wild-type SYK.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SYK spleen tyrosine kinase [ Homo sapiens ]
• Synonyms: SYK; spleen tyrosine kinase; FLJ25043; FLJ37489; DKFZp313N1010; OTTHUMP00000021628; OTTHUMP00000021629; EC 2.7.10.2; Tyrosine-protein kinase SYK
• Gene ID: 6850
• mRNA Refseq: NM_001135052
• Protein Refseq: NP_001128524
• MIM: 600085
• UniProt ID: P43405
• Chromosome Location: 9q22
• Pathway: B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Natural killer cell mediated cytotoxicity
• Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein domain specific binding; receptor signaling protein tyrosine kinase activity; transferase activity