SNRPC
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Official Full Name
small nuclear ribonucleoprotein polypeptide C -
Overview
This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant. -
Synonyms
SNRPC;small nuclear ribonucleoprotein polypeptide C;U1 small nuclear ribonucleoprotein C;U1 C;Yhc1;U1 snRNP C;U1 snRNP protein C;U1 small nuclear RNP specific C;U1C;FLJ20302
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Macaca mulatta
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SNRPC involved in several pathways and played different roles in them. We selected most pathways SNRPC participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNRPC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | HSPA8,SF3B5,SNRNP27,THOC4,PRP19,CTNNBL1,TCERG1,RBM25,HSP70,HSC70 |
Protein Function
SNRPC has several biochemical functions, for example, NOT U1 snRNA binding,mRNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNRPC itself. We selected most functions SNRPC had, and list some proteins which have the same functions with SNRPC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SRP54,ADK,RTCD1,C2orf15,MRPL37,SORBS2,DKC1,HNRNPU,SSBP1,EIF3L |
| single-stranded RNA binding | TLR7,CBX7,AGO3,NXF1,CBX6,PIWIL1,POLR2G,IFIH1,JMJD6,LONP1 |
| protein binding | SNCG,NCOR1,HBXIP,STK39,MYBPH,PRELID1,IL17A,PKN2,RBM14,RABGAP1 |
| zinc ion binding | POLR3K,PHF21A,PYGO1,UBR1,SYTL4,NSMCE2,RBM14A,MKRN2,PRDM2,ERAP1 |
| protein homodimerization activity | TCF3A,ASCL1,COQ9,CADM1,CECR1,CTBP2A,HAND1,CAMK2G,RENBP,ENPP1 |
| mRNA binding | PARK7,CPSF5,NANOS2,EIF4ENIF1,AGO2,ESRP1,MRPS7,FYTTD1,C1QBP,SNRNP35 |
Interacting Protein
SNRPC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNRPC here. Most of them are supplied by our site. Hope this information will be useful for your research of SNRPC.
RBM10;WDR83;SF3A2;RBFOX2;KHDRBS3;HNRNPF;HNRNPH2;ILF3;HNRNPD;GIGYF2;DDX42;AGGF1;WDR77;HNRNPUL1;RBM4;ssrna_ug
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References
- Kaneko, Y; Suwa, A; et al. Clinical associations with autoantibody reactivities to individual components of U1 small nuclear ribonucleoprotein. LUPUS 19:307-312(2010).
- Jiang, C; Deshmukh, US; et al. Differential Responses to Smith D Autoantigen by Mice with HLA-DR and HLA-DQ Transgenes: Dominant Responses by HLA-DR3 Transgenic Mice with Diversification of Autoantibodies to Small Nuclear Ribonucleoprotein, Double-Stranded DNA, and Nuclear Antigens. JOURNAL OF IMMUNOLOGY 184:1085-1091(2010).
