SMARCA2

  • Official Full Name

    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  • Overview

    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma;protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate;transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of;the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of;genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this;gene, which contains a trinucleotide repeat (CAG) length polymorphism.
  • Synonyms

    SMARCA2;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2;SNF2L2;probable global transcription activator SNF2L2;BAF190;BRM;hBRM;hSNF2a;SNF2;SNF2LA;Sth1p;SWI2;BAF190B;SNF2-alpha;protein brahma h

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Insect Cell
  • E.coli
  • Mammalian Cell
  • Yeast
  • His&Flag
  • His
  • GST
  • Non
  • Flag
  • His&SUMO
  • N-MBP&C-His-Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SMARCA2-01H Recombinant Human SMARCA2 Protein, His-FLAG-tagged Insect Cell Human His&Flag
SMARCA2-2657H Recombinant Human SMARCA2 protein, His-tagged E.coli Human His 1-272 aa
SMARCA2-71H Active Recombinant Human SMARCA2, His&FLAG-tagged E.coli Human His&Flag 1367-1511 a.a.
SMARCA2-159H Recombinant Human SMARCA2, GST-tagged E.coli Human GST 1367-1511 a.a.
SMARCA2-193H Recombinant Human SMARCA2 Protein, GST-tagged E.coli Human GST 1367-1511
SMARCA2-194H Recombinant Human SMARCA2 Protein, His-tagged E.coli Human His 1367-1511
SMARCA2-195H Recombinant Human SMARCA2 Protein, GST-tagged E.coli Human GST 1367-1511
SMARCA2-196H Recombinant Human SMARCA2 Protein, His-tagged E.coli Human His 1367-1493
SMARCA2-3920Z Recombinant Zebrafish SMARCA2 Mammalian Cell Zebrafish His
SMARCA2-6696C Recombinant Chicken SMARCA2 Mammalian Cell Chicken His
Kit-1866 SMARCA2 Inhibitor Screening Assay Kit Non
SMARCA2-11H Recombinant Human SMARCA2 Protein (636-1131), N-FLAG tagged Insect Cell Human Flag 636-1131
SMARCA2-13H Recombinant Human SMARCA2 Protein (1367-1511), N-GST tagged E.coli Human GST 1367-1511
SMARCA2-1523H Recombinant Human SMARCA2 Protein (700-1216 aa), His-tagged Yeast Human His 700-1216 aa
SMARCA2-194HB Recombinant Human SMARCA2 Protein, His-tagged, Biotinylated E.coli Human His 1367-1511 aa
SMARCA2-3508H Recombinant Human SMARCA2 protein, His-SUMO-tagged E.coli Human His&SUMO 700-1216aa
SMARCA2-5654H Recombinant Human SMARCA2 protein, MBP&His-Avi-tagged, Biotinylated E.coli Human N-MBP&C-His-Avi 700-1216aa

    Involved Pathway

    SMARCA2 involved in several pathways and played different roles in them. We selected most pathways SMARCA2 participated on our site, such as C-MYB transcription factor network,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor network YEATS4,ADORA2B,CBX4,CEBPB,COL1A2,MYC,SKI,CLTA,MYF6,CEBPA
    RMTs methylate histone arginines SMARCC2,SMARCB1B,SMARCD3B,SMARCE1,PBRM1L,WDR77,SMARCB1,PBRM1,PRMT7,SMARCC1
    Chromatin modifying enzymes BRD8,SUZ12A,ING3,SUZ12B,SMARCC2,C20orf20,PADI6,RBB4L,WDR77,PBRM1
    Chromatin organization COPRS,SMARCD3,MORF4L2,MSL2A,SMARCC1,KAT6A,PHF2,KDM2AA,KDM5BA,CCDC101
    E2F transcription factor network E2F4,CBX5,CES1,UXT,MYBL2,DHFR,CEBPA,PRMT5,E2F6,CDKN2C
    RB in Cancer PRMT2,RABIF,ANLN,FAF1,TOP2A,HLTF,RBP1,DCK,HMGB2
    Regulation of Androgen receptor activity SMARCE1,NR2C2,KAT7,TRIM24,APPBP2,SPDEF,GATA2,NR0B1,SENP1,SRY

    Protein Function

    SMARCA2 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA2 itself. We selected most functions SMARCA2 had, and list some proteins which have the same functions with SMARCA2. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region DNA binding TAF7L,HMGB2,PROX1,MEF2C,MTERF3,CARM1,SFPQ,TNF,KLF2A,ZFP821
    protein binding FAM129A,TOP3B,CSF1,PFN1,FASLG,BANF1,F2R,MPDZ,RGS1,BLCAP
    DNA-dependent ATPase activity MSH6,MSH4,MSH5,TOP2A,MSH3,CHD6,RAD51D,DHX36,CDK7,RAD51B
    chromatin binding RAG2,NFKB2,CRX,TDRD3,MKRN1,HHEX,TAF2,CHAF1B,TCF7,GATA2B
    ATP binding ABCG2B,BUB1B,TTBK1,AKT2L,SMC1B,PKM,MYO1H,ENTPD2,EIF4A3,UBE2D1
    RNA polymerase II transcription coactivator activity MKL1,RERE,MEF2A,CITED1,TRIM28,CITED4,ANKRD1,NCOA1,POU3F1,SOX11
    transcription coactivator activity HTATIP2,CRSP7,JUP,SIX3,SUPT7L,RNF4,SCAND1,GMEB1,SNW1,ARL2BP
    histone binding HIST1H4H,PRMT6,NOC2L,LEF1,DAXX,HIST4H4,NCL,HIST3H3,CTCFL,NASP
    helicase activity CHD6,DDX39AA,WRN,PEO1,DHX33,HELQ,BAT1,EIF4A1B,UPF1,DHX37

    Interacting Protein

    SMARCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA2.

    tat_hv112;ARID1A;ARID1B;MECP2;KHDRBS1

    Resources

    References

    • Lee, D; Moon, S; et al. NMR and Fluorescence Studies of DNA Binding Domain of INI1/hSNF5. BULLETIN OF THE KOREAN CHEMICAL SOCIETY 35:2753-2757(2014).
    • Zhang, LY; Ma, P; et al. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. MOLECULAR VISION 20:56-72(2014).

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