SEMA4A
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Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -
Overview
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
SEMA4A;sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A;semaphorin-4A;sema B;semaphorin-B;semaphorin 4A;SemB;Semab;AI132332
Recombinant Proteins
- Mouse
- Human
- HEK293
- CHO
- Human Cell
- HEK293T
- Mammalian cells
- His
- Fc
- Non
- Myc&DDK
Involved Pathway
SEMA4A involved in several pathways and played different roles in them. We selected most pathways SEMA4A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | SEMA3B,ANK2B,CDK5,SEMA5A,DAB2IPB,FYN,PEA15,LRRC4C,CLTC,ITGB1 |
Protein Function
SEMA4A has several biochemical functions, for example, chemorepellent activity,NOT neuropilin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA4A itself. We selected most functions SEMA4A had, and list some proteins which have the same functions with SEMA4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemorepellent activity | SEMA3C,SEMA6C,SEMA4B,SEMA4BA,SEMA6D,NRG3,FLRT2,SEMA3FA,SLIT2,UBE4A |
| NOT neuropilin binding | SEMA4B,SEMA4D,SEMA4C,SEMA4BA |
| protein binding | SCARF1,SMAD2,EMILIN1,C1orf65,PUS7L,LRRK1,ZHX1,SH2D2A,POLD2,ZNF133 |
| semaphorin receptor binding | SEMA3A,SEMA4D,SEMA3GB,SEMA6DL,SEMA5A,SEMA4BA,SH3BGRL3,SEMA3BL,SEMA3G,SEMA3D |
Interacting Protein
SEMA4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA4A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA4A.
PLXND1;PLXNB2;PLXNB1;PLXNB3;DDX54
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References
- Ishii, H; Kubo, T; et al. Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402:168-172(2010).
- Yukawa, K; Tanaka, T; et al. Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 16:115-118(2005).
