SDC2
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Official Full Name
syndecan 2 -
Overview
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008] -
Synonyms
SDC2;syndecan 2;HSPG;CD362;HSPG1;SYND2;syndecan-2;fibroglycan;syndecan proteoglycan 2;heparan sulfate proteoglycan core protein;cell surface-associated heparan sulfate proteoglycan 1;heparan sulfate proteoglycan 1, cell surface-associated
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Mus musculus
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- E.coli expression system
- Human Cell
- His
- Non
- His&Fc&Avi
- Fc
Involved Pathway
SDC2 involved in several pathways and played different roles in them. We selected most pathways SDC2 participated on our site, such as Cell adhesion molecules (CAMs),Malaria,Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | THBS2,DARC,HBA1,PECAM1,VCAM1,ICAM1,COMP,IFNG,IL18,IL6 |
| Proteoglycans in cancer | ERBB3,IGF1R,PRKACA,RRAS2,HSPB2,VTN,ROCK1,FN1,RHOA,MAPK11 |
| Cell adhesion molecules (CAMs) | NEO1,SELE,HLA-DRB4,CNTN1,CLDN18,NCAM1A,MHC2DAB,MHC2A,LRRC4B,CLDN5B |
Protein Function
SDC2 has several biochemical functions, for example, PDZ domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDC2 itself. We selected most functions SDC2 had, and list some proteins which have the same functions with SDC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF365,YY1AP1,HEYL,VARS2,HSPB9,GATA2,RGS14,CARD11,TAE1,PDK1 |
| PDZ domain binding | ATP2B1B,SNTA1,ATP2B4,ERC1,ATP2B1,ADRB1,LNX2,PSEN1,ATP2B1A,GRASP |
Interacting Protein
SDC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SDC2.
CASK;SDCBP;MYB;RASA1;GAMMAHV.ORF30;SERPINA1;NF1;CYP2C18;BAG6;PPP3CC;mtlA;CSNK2A2;PYHIN1
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References
- Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
- Zhang, YH; Wang, NN; et al. Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity. JOURNAL OF BIOLOGICAL CHEMISTRY 288:12090-12101(2013).
