Active Recombinant Mouse SDC2 Protein

• Cat.No.: SDC2-14790M
• Product Overview: Recombinant mouse Syndecan-2 (Glu19-Phe141) protein with C-terminal TGHHH HHHHHGGQ was expressed in HEK293 cell.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Non
• Description: Syndecan-2, previously known as fibroglycan, is a member of the syndecan family of Type 1 transmembrane proteins carrying heparan sulfate and chondroitin sulfate glycosaminoglycans. The syndecan family consists of four transmembrane proteoglycans divided into two subfamilies (Syndecan -1 , -3 and Syndecan-2 ,- 4) based on their sequence homology. The four syndecans have conserved cytoplasmic domains which enables them to associate with cytoskeletal proteins and signaling molecules. The cytoplasmic tail of Syndecan-2 has both serine and tyrosine phosphorylation sites. Non-covalent homodimerization of Syndecan-2 is dependent on the transmembrane domain. Syndecan-2 is expressed in endothelial, mesenchymal, carcinoma cells, and is the predominant syndecan expressed during embryonic development. It functions as a co-receptor for enzymes, growth factors, and cytokines, and contributes to the formation of cytokine gradients through extracellular shedding. Syndecan-2 interacts with high affinity receptors and integrins to modulate intracellular signaling. Syndecan is also involved in matrix assembly and remodeling. It controls laminin and fibronectin matrix assembly into a fibrillar matrix.
• Bio-activity: When mouse Syndecan-2 is immobilized at 5 μg/mL, human FGF-basic binds with EC50 of 2 - 8 ng/mL.
• Molecular Mass: 14.9 kDa
• N-terminal Sequence Analysis: Glu
• Endotoxin: Less than 0.1 EU per μg of protein as determined by the LAL method.
• Purity: >95% as determined by Coomassie stained SDS-PAGE.
• Applications: Bioassay
• Storage: Unopened vial can be stored between 2 centigrade and 8 centigrade for one month, at -20 centigrade for six months, or at -70 centigrade for one year. For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored at -20 centigrade to -70 centigrade. Stock solutions can also be prepared at 50 - 100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2-1% BSA or HSA and stored in working aliquots at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
• Concentration: 200 μg/mL
• Storage Buffer: 0.22 μm filtered protein solution is in PBS, pH 7.2.

Gene Information

• Gene Name: Sdc2 syndecan 2 [ Mus musculus (house mouse) ]
• Official Symbol: Sdc2
• Synonyms: SDC2; Synd2; Hspg1; Fibroglycan; Hspg1; Synd2; AA960457; syndecan-2; 4833414L08Rik; syndecan-2; HSPG; fibroglycan; heparan sulfate proteoglycan 1, cell surface-associated (fibroglycan); heparan sulfate proteoglycan core protein
• Gene ID: 15529
• mRNA Refseq: NM_008304
• Protein Refseq: NP_032330
• UniProt ID: P43407