Active Recombinant Human Syndecan 2, His-tagged

• Cat.No.: SDC2-501H
• Product Overview: Recombinant Human SDC2protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Glu19-Glu144.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 19-144 a.a.
• Description: SDC2, previouslyknown as fibroglycan or heparan sulfate proteoglycan, is a member of thesyndecan family of Type 1 transmembrane proteins capable of carrying heparansulfate (HS) and chondroitin sulfate glycosaminoglycans. The four vertebratesyndecans show conserved cytoplasmic domains and divergent extracellularportions (except for GAG attachment sites). Among the Syndecans, SDC2 is mostsimilar to SDC4.
• Form: Lyophilized from a0.2 μm filtered solution in Tris-Citrate and NaCl.
• N-terminalSequence: Glu19
• Molecular Weight: 14.8 kDa
• Activity: Measuredby its binding ability in a functional ELISA. Immobilized rhSDC2 at 200 ng/mL(100 mL/well) can bind rhFGFbasic with a linear range of 0.1-10 ng/mL
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 35-45kDa, reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100 μg/ mLin sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.

Gene Information

• Gene Name: SDC2 syndecan 2 [ Homosapiens ]
• Official Symbol: SDC2
• Synonyms: SDC2; syndecan 2; HSPG;CD362; HSPG1; SYND2; syndecan-2; fibroglycan; syndecan proteoglycan 2;heparan sulfate proteoglycan core protein; cell surface-associated heparansulfate proteoglycan 1; heparan sulfate proteoglycan 1, cellsurface-associated; OTTHUMP00000227223; OTTHUMP00000227224;OTTHUMP00000227225; OTTHUMP00000227226; OTTHUMP00000227227;OTTHUMP00000227228; CD362 antigen
• Gene ID: 6383
• mRNA Refseq: NM_002998
• Protein Refseq: NP_002989
• MIM: 142460
• UniProt ID: P34741
• Chromosome Location: 8q22-q23
• Pathway: Cell adhesion molecules (CAMs);ECM-receptor interaction; FGF signaling pathway; Malaria; Proteogylcansyndecan-mediated signaling events; Syndecan-2-mediated signaling events;TGF-beta Receptor Signaling Pathway
• Function: PDZ domain binding; cytoskeletal proteinbinding; protein binding