PF4
-
Official Full Name
platelet factor 4 -
Overview
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012] -
Synonyms
PF4;platelet factor 4;PF-4;CXCL4;SCYB4;iroplact;oncostatin-A;C-X-C motif chemokine 4;chemokine (C-X-C motif) ligand 4
Recombinant Proteins
- Human
- Mouse
- Rat
- Cattle
- Horse
- Rabbit
- Pig
- Bovine
- E.coli
- Human
- Human Platelet
- Mammalian Cell
- HEK293
- Human Cells
- Mammalian cells
- HEK293T
- Yeast
- GST
- Non
- His
- His&GST
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- mFc
- Fc
- N-His&C-Myc
Involved Pathway
PF4 involved in several pathways and played different roles in them. We selected most pathways PF4 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | PRKACB,PLCB3,CXCR2,CCL26,PIK3CA,CXCL6,LOC100033925,HCK,MAPK1,STAT5B |
| Cytokine-cytokine receptor interaction | CCL1,CCL19B,CXCL2,IL25,IL22RA2,CNTF,IFNAR2,CD70,TNFSF9,PDGFAB |
Protein Function
PF4 has several biochemical functions, for example, CXCR3 chemokine receptor binding,chemokine activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PF4 itself. We selected most functions PF4 had, and list some proteins which have the same functions with PF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | XCL1,CCL28,Ccl21a,PF4V1,CCL24,CCL19A.1,CCL34B.1,CCL27,CCL34B.9,CXCL5 |
| CXCR3 chemokine receptor binding | CXCL13,CXCL11,CXCL9,CXCL10,CXCL11.8 |
| heparin binding | ABP1,Itgam&Itgb2,LPL,WISP1A,LTBP2,APOA5,LTF,SLIT2,KNG1,FBLN7 |
Interacting Protein
PF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PF4.
PLEK;a41_vaccw
Resources
Research Area
Angiogenesis InhibitorOther Coagulation Cascade Molecules
Inflammatory Mediators
Regulatory T Cells (Tregs)
Megakaryocytes
CXC Chemokines
Angiogenesis Inhibitor in Cancer
Related Services
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References
- Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
- Matsuo, T; Motohashi, S; et al. Production of Anti-platelet Factor 4/Heparin Complex Antibodies After Cardiovascular Surgery. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:177-180(2015).
